EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies

por Derer, Stefanie, Lohse, Stefan, Valerius, Thomas
Publicado 2013

Targeting Myeloid Checkpoint Molecules in Combination With Antibody Therapy: A Novel Anti-Cancer Strategy With IgA Antibodies?

por Chan, Chilam, Lustig, Marta, Baumann, Niklas, Valerius, Thomas, van Tetering, Geert, Leusen, Jeanette H. W.
Publicado 2022

Corrigendum: Targeting myeloid checkpoint molecules in combination with antibody therapy: A novel anti-cancer strategy with IgA antibodies?

por Chan, Chilam, Lustig, Marta, Baumann, Niklas, Valerius, Thomas, van Tetering, Geert, Leusen, Jeanette H. W.
Publicado 2022

HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity

por Peipp, Matthias, Derer, Stefanie, Lohse, Stefan, Staudinger, Matthias, Klausz, Katja, Valerius, Thomas, Gramatzki, Martin, Kellner, Christian
Publicado 2015

A novel Fc-engineered human ICAM-1/CD54 antibody with potent anti-myeloma activity developed by cellular panning of phage display libraries

por Klausz, Katja, Cieker, Michael, Kellner, Christian, Oberg, Hans-Heinrich, Kabelitz, Dieter, Valerius, Thomas, Burger, Renate, Gramatzki, Martin, Peipp, Matthias
Publicado 2017

Specific Targeting of Lymphoma Cells Using Semisynthetic Anti-Idiotype Shark Antibodies

por Macarrón Palacios, Arturo, Grzeschik, Julius, Deweid, Lukas, Krah, Simon, Zielonka, Stefan, Rösner, Thies, Peipp, Matthias, Valerius, Thomas, Kolmar, Harald
Publicado 2020

Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy

por Klausz, Katja, Cieker, Michael, Kellner, Christian, Rösner, Thies, Otte, Anna, Krohn, Steffen, Lux, Anja, Nimmerjahn, Falk, Valerius, Thomas, Gramatzki, Martin, Peipp, Matthias
Publicado 2020

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

por Chan, Chilam, Lustig, Marta, Jansen, J. H. Marco, Garcia Villagrasa, Laura, Raymakers, Leon, Daamen, Lois A., Valerius, Thomas, van Tetering, Geert, Leusen, Jeanette H. W.
Publicado 2023

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2 m(1) antibody

por Brunke, Christina, Lohse, Stefan, Derer, Stefanie, Peipp, Matthias, Boross, Peter, Kellner, Christian, Beyer, Thomas, Dechant, Michael, Royle, Louise, Liew, Li Phing, Leusen, Jeanette HW, Valerius, Thomas
Publicado 2013

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

por Brandsma, Arianne M., Bondza, Sina, Evers, Mitchell, Koutstaal, Rosanne, Nederend, Maaike, Jansen, J. H. Marco, Rösner, Thies, Valerius, Thomas, Leusen, Jeanette H. W., ten Broeke, Toine
Publicado 2019

Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma

por Evers, Mitchell, Stip, Marjolein, Keller, Kaylee, Willemen, Hanneke, Nederend, Maaike, Jansen, Marco, Chan, Chilam, Budding, Kevin, Nierkens, Stefan, Valerius, Thomas, Meyer-Wentrup, Friederike, Eijkelkamp, Niels, Leusen, Jeanette
Publicado 2021

Engineering of CD19 Antibodies: A CD19-TRAIL Fusion Construct Specifically Induces Apoptosis in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells In Vivo

por Winterberg, Dorothee, Lenk, Lennart, Oßwald, Maren, Vogiatzi, Fotini, Gehlert, Carina Lynn, Frielitz, Fabian-Simon, Klausz, Katja, Rösner, Thies, Valerius, Thomas, Trauzold, Anna, Peipp, Matthias, Kellner, Christian, Schewe, Denis Martin
Publicado 2021

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

por Meyer, Saskia, Nederend, Maaike, Jansen, J.H. Marco, Reiding, Karli R., Jacobino, Shamir R., Meeldijk, Jan, Bovenschen, Niels, Wuhrer, Manfred, Valerius, Thomas, Ubink, Ruud, Boross, Peter, Rouwendal, Gerard, Leusen, Jeanette H.W.
Publicado 2015

Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering

por Roßkopf, Sophia, Eichholz, Klara Marie, Winterberg, Dorothee, Diemer, Katarina Julia, Lutz, Sebastian, Münnich, Ira Alexandra, Klausz, Katja, Rösner, Thies, Valerius, Thomas, Schewe, Denis Martin, Humpe, Andreas, Gramatzki, Martin, Peipp, Matthias, Kellner, Christian
Publicado 2020

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

por Neijssen, Joost, Cardoso, Rosa M.F., Chevalier, Kristen M., Wiegman, Luus, Valerius, Thomas, Anderson, G. Mark, Moores, Sheri L., Schuurman, Janine, Parren, Paul W.H.I., Strohl, William R., Chiu, Mark L.
Publicado 2021

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies

por Evers, Mitchell, Ten Broeke, Toine, Jansen, J.H. Marco, Nederend, Maaike, Hamdan, Firas, Reiding, Karli R., Meyer, Saskia, Moerer, Petra, Brinkman, Iris, Rösner, Thies, Lebbink, Robert Jan, Valerius, Thomas, Leusen, Jeanette H.W.
Publicado 2020

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab

por Baumann, Niklas, Arndt, Christian, Petersen, Judith, Lustig, Marta, Rösner, Thies, Klausz, Katja, Kellner, Christian, Bultmann, Miriam, Bastian, Lorenz, Vogiatzi, Fotini, Leusen, Jeanette H. W., Burger, Renate, Schewe, Denis M., Peipp, Matthias, Valerius, Thomas
Publicado 2022

Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions

por Baumann, Niklas, Rösner, Thies, Jansen, J. H. Marco, Chan, Chilam, Marie Eichholz, Klara, Klausz, Katja, Winterberg, Dorothee, Müller, Kristina, Humpe, Andreas, Burger, Renate, Peipp, Matthias, Schewe, Denis M., Kellner, Christian, Leusen, Jeanette H. W., Valerius, Thomas
Publicado 2021

Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody

por Gehlert, Carina Lynn, Rahmati, Pegah, Boje, Ammelie Svea, Winterberg, Dorothee, Krohn, Steffen, Theocharis, Thomas, Cappuzzello, Elisa, Lux, Anja, Nimmerjahn, Falk, Ludwig, Ralf J., Lustig, Marta, Rösner, Thies, Valerius, Thomas, Schewe, Denis Martin, Kellner, Christian, Klausz, Katja, Peipp, Matthias
Publicado 2022

Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells

por Lustig, Marta, Chan, Chilam, Jansen, J. H. Marco, Bräutigam, Maria, Kölling, Max A., Gehlert, Carina Lynn, Baumann, Niklas, Mester, Simone, Foss, Stian, Andersen, Jan Terje, Bastian, Lorenz, Sondermann, Peter, Peipp, Matthias, Burger, Renate, Leusen, Jeanette H. W., Valerius, Thomas
Publicado 2023