MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

por Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas
Publicado 2018

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

por Green, Alanna C., Marttila, Petra, Kiweler, Nicole, Chalkiadaki, Christina, Wiita, Elisée, Cookson, Victoria, Lesur, Antoine, Eiden, Kim, Bernardin, François, Vallin, Karl S. A., Borhade, Sanjay, Long, Maeve, Ghahe, Elahe Kamali, Jiménez-Alonso, Julio J., Jemth, Ann-Sofie, Loseva, Olga, Mortusewicz, Oliver, Meyers, Marianne, Viry, Elodie, Johansson, Annika I., Hodek, Ondřej, Homan, Evert, Bonagas, Nadilly, Ramos, Louise, Sandberg, Lars, Frödin, Morten, Moussay, Etienne, Slipicevic, Ana, Letellier, Elisabeth, Paggetti, Jérôme, Sørensen, Claus Storgaard, Helleday, Thomas, Henriksson, Martin, Meiser, Johannes
Publicado 2023

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

por Bonagas, Nadilly, Gustafsson, Nina M. S., Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisée, Borhade, Sanjay, Green, Alanna C., Vallin, Karl S. A., Sarno, Antonio, Svensson, Richard, Göktürk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E., Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R., Bengtsson, Christoffer, Paulin, Cynthia B. J., Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Färnegårdh, Katarina, Krämer, Andreas, Garg, Neeraj, Michel, Maurice, Häggblad, Sara, Jarvius, Malin, Kalderén, Christina, Jensen, Amanda Bögedahl, Almlöf, Ingrid, Karsten, Stella, Zhang, Si Min, Häggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Björn, Nekhotiaeva, Natalia, Klingegård, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjöberg, Birger, Vargas, Irene L., Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E., Arvidsson, Per I., Scobie, Martin, Meiser, Johannes, Stenmark, Pål, Berglund, Ulrika Warpman, Homan, Evert J., Helleday, Thomas
Publicado 2022