GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

por Valvezan, Alexander J., Klein, Peter S.
Publicado 2012

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

por Valvezan, Alexander J., Huang, Jian, Lengner, Christopher J., Pack, Michael, Klein, Peter S.
Publicado 2014

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)

por Housden, Benjamin E., Li, Zhongchi, Kelley, Colleen, Wang, Yuanli, Hu, Yanhui, Valvezan, Alexander J., Manning, Brendan D., Perrimon, Norbert
Publicado 2017

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R

por Filippakis, Harilaos, Alesi, Nicola, Ogorek, Barbara, Nijmeh, Julie, Khabibullin, Damir, Gutierrez, Catherine, Valvezan, Alexander J., Cunningham, James, Priolo, Carmen, Henske, Elizabeth P.
Publicado 2017

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

por Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Publicado 2021

The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish

por Liu, Xiaolei, Jones, William D., Quesnel-Vallières, Mathieu, Devadiga, Sudhish A., Lorent, Kristin, Valvezan, Alexander J., Myers, Rebecca L., Li, Ning, Lengner, Christopher J., Barash, Yoseph, Pack, Michael, Klein, Peter S.
Publicado 2023

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

por McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.
Publicado 2022

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

por Dai, Weiwei, Shen, Jianliang, Yan, Junrong, Bott, Alex J., Maimouni, Sara, Daguplo, Heineken Q., Wang, Yujue, Khayati, Khoosheh, Guo, Jessie Yanxiang, Zhang, Lanjing, Wang, Yongbo, Valvezan, Alexander, Ding, Wen-Xing, Chen, Xin, Su, Xiaoyang, Gao, Shenglan, Zong, Wei-Xing
Publicado 2022