MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons

por Fuller, Abby D., Van Eldik, Linda J.
Publicado 2008

In vivo Brainstem Imaging in Alzheimer’s Disease: Potential for Biomarker Development

por Braun, David J., Van Eldik, Linda J.
Publicado 2018

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

por Xing, Bin, Bachstetter, Adam D, Van Eldik, Linda J
Publicado 2011

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

por Xing, Bin, Bachstetter, Adam D., Van Eldik, Linda J.
Publicado 2013

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

por Bachstetter, Adam D, Xing, Bin, Van Eldik, Linda J
Publicado 2014

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults

por Xing, Bin, Bachstetter, Adam D., Van Eldik, Linda J.
Publicado 2014

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice

por Morganti, Josh M., Goulding, Danielle S., Van Eldik, Linda J.
Publicado 2019

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

por Thompson, Wendy L, Karpus, William J, Van Eldik, Linda J
Publicado 2008

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

por Webster, Scott J, Bachstetter, Adam D, Van Eldik, Linda J
Publicado 2013

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

por Bachstetter, Adam D., Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2014

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid

por Craft, Jeffrey M, Watterson, D Martin, Hirsch, Emmet, Van Eldik, Linda J
Publicado 2005

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target

por Borders, Aaron S, de Almeida, Lucia, Van Eldik, Linda J, Watterson, D Martin
Publicado 2008

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of th...

por Bachstetter, Adam D, Webster, Scott J, Van Eldik, Linda J, Cambi, Franca
Publicado 2013

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

por Braun, David J., Dimayuga, Edgardo, Morganti, Josh M., Van Eldik, Linda J.
Publicado 2020

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse mo...

por Lloyd, Eric, Somera-Molina, Kathleen, Van Eldik, Linda J, Watterson, D Martin, Wainwright, Mark S
Publicado 2008

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

por Webster, Scott J., Bachstetter, Adam D., Nelson, Peter T., Schmitt, Frederick A., Van Eldik, Linda J.
Publicado 2014

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

por Early, Alexandria N., Gorman, Amy A., Van Eldik, Linda J., Bachstetter, Adam D., Morganti, Josh M.
Publicado 2020

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

por Bachstetter, Adam D, Xing, Bin, de Almeida, Lucia, Dimayuga, Edgardo R, Watterson, D Martin, Van Eldik, Linda J
Publicado 2011

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

por Bachstetter, Adam D, Webster, Scott J, Goulding, Danielle S, Morton, Jonathan E, Watterson, D Martin, Van Eldik, Linda J
Publicado 2015

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

por Zhou, Zhengqiu, Bachstetter, Adam D., Späni, Claudia B., Roy, Saktimayee M., Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2017