Bile Salts by the Back Road

por Oude Elferink, Ronald P.J., Van De Graaf, Stan F.J.
Publicado 2023

Mechanistic insights into the inhibition of NTCP by myrcludex B

por Donkers, Joanne M., Appelman, Monique D., van de Graaf, Stan F.J.
Publicado 2019

Insufficient evidence for NTCP activity in stellate cells

por Kunst, Roni F, Paulusma, Coen C, van de Graaf, Stan F J
Publicado 2022

The Somatic FAH c.1061C>A Change Counteracts the Frequent FAH c.1062+5G>A Mutation and Permits U1snRNA-Based Splicing Correction

por Scalet, Daniela, Sacchetto, Claudia, Bernardi, Francesco, Pinotti, Mirko, van de Graaf, Stan F.J., Balestra, Dario
Publicado 2018

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

por Appelman, Monique D., Chakraborty, Anindita, Protzer, Ulrike, McKeating, Jane A., van de Graaf, Stan F. J.
Publicado 2017

Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology

por Kunst, Roni F., Verkade, Henkjan J., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2021

Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β

por van de Wiel, Sandra M.W., de Waart, D. Rudi, Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2017

Identification of FDA-approved drugs targeting the Farnesoid X Receptor

por van de Wiel, Sandra M. W., Bijsmans, Ingrid T. G. W., van Mil, Saskia W. C., van de Graaf, Stan F. J.
Publicado 2019

An Exon-Specific Small Nuclear U1 RNA (ExSpeU1) Improves Hepatic OTC Expression in a Splicing-Defective spf/ash Mouse Model of Ornithine Transcarbamylase Deficiency

por Balestra, Dario, Ferrarese, Mattia, Lombardi, Silvia, Ziliotto, Nicole, Branchini, Alessio, Petersen, Naomi, Bosma, Piter, Pinotti, Mirko, van de Graaf, Stan F. J.
Publicado 2020

Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA

por Prins, Marileen M. C., Giugliano, Francesca P., van Roest, Manon, van de Graaf, Stan F. J., Koelink, Pim J., Wildenberg, Manon E.
Publicado 2021

OTC intron 4 variations mediate pathogenic splicing patterns caused by the c.386G>A mutation in humans and spf(ash) mice, and govern susceptibility to RNA-based therapies

por Sacchetto, Claudia, Peretto, Laura, Baralle, Francisco, Maestri, Iva, Tassi, Francesca, Bernardi, Francesco, van de Graaf, Stan F. J., Pagani, Franco, Pinotti, Mirko, Balestra, Dario
Publicado 2021

Reply

por Roscam Abbing, Reinout L.P., Kuipers, Folkert, Paulusma, Coen C., Verkade, Henkjan J., Groen, Albert K., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2020

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization

por Bruurs, Lucas J.M., Donker, Lisa, Zwakenberg, Susan, Zwartkruis, Fried J., Begthel, Harry, Knisely, A.S., Posthuma, George, van de Graaf, Stan F.J., Paulusma, Coen C., Bos, Johannes L.
Publicado 2015

Na(+)‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice

por Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Fuchs, Claudia D., Haazen, Lizette C.M., Beuers, Ulrich, Trauner, Michael, Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2018

A Compensatory U1snRNA Partially Rescues FAH Splicing and Protein Expression in a Splicing-Defective Mouse Model of Tyrosinemia Type I

por Balestra, Dario, Scalet, Daniela, Ferrarese, Mattia, Lombardi, Silvia, Ziliotto, Nicole, C. Croes, Chrystal, Petersen, Naomi, Bosma, Piter, Riccardi, Federico, Pagani, Franco, Pinotti, Mirko, van de Graaf, Stan F. J.
Publicado 2020

Mutational Analysis of ATP8B1 in Patients with Chronic Pancreatitis

por van der Woerd, Wendy L., van Haaften-Visser, Désirée Y., van de Graaf, Stan F. J., Férec, Claude, Masson, Emmanuelle, Stapelbroek, Janneke M., Bugert, Peter, Witt, Heiko, Houwen, Roderick H. J.
Publicado 2013

Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

por Donkers, Joanne M., Zehnder, Benno, van Westen, Gerard J. P., Kwakkenbos, Mark J., IJzerman, Adriaan P., Oude Elferink, Ronald P. J., Beuers, Ulrich, Urban, Stephan, van de Graaf, Stan F. J.
Publicado 2017

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity

por Donkers, Joanne M., Roscam Abbing, Reinout L.P., van Weeghel, Michel, Levels, Johannes H.M., Boelen, Anita, Schinkel, Alfred H., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2020

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

por Kunst, Roni F., de Waart, Dirk R., Wolters, Frank, Duijst, Suzanne, Vogels, Esther W., Bolt, Isabelle, Verheij, Joanne, Beuers, Ulrich, Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2022

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na(+)‐Taurocholate Cotransporting Polypeptide

por Robin, Marion J.D., Appelman, Monique D., Vos, Harmjan R., van Es, Robert M., Paton, James C., Paton, Adrienne W., Burgering, Boudewijn, Fickert, Peter, Heijmans, Jarom, van de Graaf, Stan F.J.
Publicado 2018