Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

por Sharma, Shubh, Garfield, Alastair S., Shah, Bhavik, Kleyn, Patrick, Ichetovkin, Ilia, Moeller, Ida Hatoum, Mowrey, William R., Van der Ploeg, Lex H.T.
Publicado 2019

Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity

por Jacques, Vincent, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Czarnik, Anthony W., Divakaruni, Ajit S., Fouqueray, Pascale, Murphy, Anne N., Van der Ploeg, Lex H.T., DeWitt, Sheila
Publicado 2021

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

por Clemmensen, Christoffer, Finan, Brian, Fischer, Katrin, Tom, Robby Zachariah, Legutko, Beata, Sehrer, Laura, Heine, Daniela, Grassl, Niklas, Meyer, Carola W, Henderson, Bart, Hofmann, Susanna M, Tschöp, Matthias H, Van der Ploeg, Lex HT, Müller, Timo D
Publicado 2015

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

por Collet, Tinh-Hai, Dubern, Béatrice, Mokrosinski, Jacek, Connors, Hillori, Keogh, Julia M., Mendes de Oliveira, Edson, Henning, Elana, Poitou-Bernert, Christine, Oppert, Jean-Michel, Tounian, Patrick, Marchelli, Florence, Alili, Rohia, Le Beyec, Johanne, Pépin, Dominique, Lacorte, Jean-Marc, Gottesdiener, Andrew, Bounds, Rebecca, Sharma, Shubh, Folster, Cathy, Henderson, Bart, O'Rahilly, Stephen, Stoner, Elizabeth, Gottesdiener, Keith, Panaro, Brandon L., Cone, Roger D., Clément, Karine, Farooqi, I. Sadaf, Van der Ploeg, Lex H.T.
Publicado 2017