Single stranded adeno-associated virus achieves efficient gene transfer to anterior segment in the mouse eye

por Wang, Li, Xiao, Ru, Andres-Mateos, Eva, Vandenberghe, Luk H.
Publicado 2017

Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction

por Suzuki, Jun, Hashimoto, Ken, Xiao, Ru, Vandenberghe, Luk H., Liberman, M. Charles
Publicado 2017

Corrigendum: Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction

por Suzuki, Jun, Hashimoto, Ken, Xiao, Ru, Vandenberghe, Luk H., Liberman, M. Charles
Publicado 2017

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

por Wassmer, Sarah J., Carvalho, Livia S., György, Bence, Vandenberghe, Luk H., Maguire, Casey A.
Publicado 2017

Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae

por Omichi, Ryotaro, Yoshimura, Hidekane, Shibata, Seiji B., Vandenberghe, Luk H., Smith, Richard J.H.
Publicado 2020

Immunogenicity of an AAV-Based COVID-19 Vaccine in Murine Models of Obesity and Aging

por Maciorowski, Dawid, Diop, Cheikh, Bhatt, Urja, Estelien, Reynette, Li, Dan, Chauhan, Ruchi, Vandenberghe, Luk H., Zabaleta, Nerea
Publicado 2022

Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting

por Carvalho, Livia S., Turunen, Heikki T., Wassmer, Sarah J., Luna-Velez, María V., Xiao, Ru, Bennett, Jean, Vandenberghe, Luk H.
Publicado 2017

Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study

por Shen, Junhui, Xiao, Ru, Bair, Jeffrey, Wang, Fang, Vandenberghe, Luk H., Dartt, Darlene, Baranov, Petr, Ng, Yin Shan Eric
Publicado 2018

AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina

por Vandenberghe, Luk H., Bell, Peter, Maguire, Albert M., Xiao, Ru, Hopkins, Tim B., Grant, Rebecca, Bennett, Jean, Wilson, James M.
Publicado 2013

Correction: AAV9 Targets Cone Photoreceptors in the Nonhuman Primate Retina

por Vandenberghe, Luk H., Bell, Peter, Maguire, Albert M., Xiao, Ru, Hopkins, Tim B., Grant, Rebecca, Bennett, Jean, Wilson, James M.
Publicado 2013

Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65

por Hudry, Eloise, Andres-Mateos, Eva, Lerner, Eli P., Volak, Adrienn, Cohen, Olivia, Hyman, Bradley T., Maguire, Casey A., Vandenberghe, Luk H.
Publicado 2018

Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

por Kumar, Prashant, Wang, Michael, Kumru, Ozan S., Hickey, John M., Sanmiguel, Julio, Zabaleta, Nerea, Vandenberghe, Luk H., Joshi, Sangeeta B., Volkin, David B.
Publicado 2023

High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography

por Florea, Michael, Nicolaou, Fotini, Pacouret, Simon, Zinn, Eric M., Sanmiguel, Julio, Andres-Mateos, Eva, Unzu, Carmen, Wagers, Amy J., Vandenberghe, Luk H.
Publicado 2022

Gene Therapy Preserves Retinal Structure and Function in a Mouse Model of NMNAT1-Associated Retinal Degeneration

por Greenwald, Scott H., Brown, Emily E., Scandura, Michael J., Hennessey, Erin, Farmer, Raymond, Pawlyk, Basil S., Xiao, Ru, Vandenberghe, Luk H., Pierce, Eric A.
Publicado 2020

Genome editing abrogates angiogenesis in vivo

por Huang, Xionggao, Zhou, Guohong, Wu, Wenyi, Duan, Yajian, Ma, Gaoen, Song, Jingyuan, Xiao, Ru, Vandenberghe, Luk, Zhang, Feng, D’Amore, Patricia A., Lei, Hetian
Publicado 2017

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints

por Vandenberghe, Luk H., Breous, Ekaterina, Nam, Hyun-Joo, Gao, Guangping, Xiao, Ru, Sandhu, Arbans, Johnston, Julie, Debyser, Zeger, Agbandje-McKenna, Mavis, Wilson, James M.
Publicado 2009

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

por Landegger, Lukas D., Pan, Bifeng, Askew, Charles, Wassmer, Sarah, Gluck, Sarah, Galvin, Alice, Taylor, Ruth, Forge, Andrew, Stankovic, Konstantina M., Holt, Jeffrey R., Vandenberghe, Luk H.
Publicado 2017

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

por Cronin, Therese, Vandenberghe, Luk H, Hantz, Péter, Juttner, Josephine, Reimann, Andreas, Kacsó, Ágota–Enikő, Huckfeldt, Rachel M, Busskamp, Volker, Kohler, Hubertus, Lagali, Pamela S, Roska, Botond, Bennett, Jean
Publicado 2014

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis

por Kassim, Sadik H., Li, Hui, Vandenberghe, Luk H., Hinderer, Christian, Bell, Peter, Marchadier, Dawn, Wilson, Aisha, Cromley, Debra, Redon, Valeska, Yu, Hongwei, Wilson, James M., Rader, Daniel J.
Publicado 2010

Isolation and Characterization of Adenoviruses Persistently Shed from the Gastrointestinal Tract of Non-Human Primates

por Roy, Soumitra, Vandenberghe, Luk H., Kryazhimskiy, Sergey, Grant, Rebecca, Calcedo, Roberto, Yuan, Xin, Keough, Martin, Sandhu, Arbans, Wang, Qiang, Medina-Jaszek, C. Angelica, Plotkin, Joshua B., Wilson, James M.
Publicado 2009