2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

por Davis, Sarah M., Sousa, Jacquelyn, Vangjeli, Lorenc, Hassler, Matthew R., Echeverria, Dimas, Knox, Emily, Turanov, Anton A., Alterman, Julia F., Khvorova, Anastasia
Publicado 2020

RNAi-based modulation of IFN-γ signaling in skin

por Tang, Qi, Sousa, Jacquelyn, Echeverria, Dimas, Fan, Xueli, Hsueh, Ying-Chao, Afshari, Khashayar, MeHugh, Nicholas, Cooper, David A., Vangjeli, Lorenc, Monopoli, Kathryn, Okamura, Ken, Biscans, Annabelle, Clauss, Adam, Harris, John E., Khvorova, Anastasia
Publicado 2022

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

por Yenilmez, Batuhan, Wetoska, Nicole, Kelly, Mark, Echeverria, Dimas, Min, Kyounghee, Lifshitz, Lawrence, Alterman, Julia F., Hassler, Matthew R., Hildebrand, Samuel, DiMarzio, Chloe, McHugh, Nicholas, Vangjeli, Lorenc, Sousa, Jacquelyn, Pan, Meixia, Han, Xianlin, Brehm, Michael A., Khvorova, Anastasia, Czech, Michael P.
Publicado 2022