Pharmacokinetics, Safety, and Tolerability of GLPG0259, a Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) Inhibitor, Given as Single and Multiple Doses to He...

por Namour, Florence, Vanhoutte, Frédéric P., Beetens, Johan, Blockhuys, Stan, Weer, Marc De, Wigerinck, Piet
Publicado 2012

Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

por Namour, Florence, Galien, René, Van Kaem, Tim, Van der Aa, Annegret, Vanhoutte, Frédéric, Beetens, Johan, van't Klooster, Gerben
Publicado 2016

A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX‐02 in Healthy Subjects

por Leubitz, Andi, Vanhoutte, Frederic, Hu, Ming‐yi, Porter, Kaela, Gordon, Efrat, Tencer, Kathleen, Campbell, Kathleen, Banks, Kate, Haverty, Tom
Publicado 2021

Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Heal...

por Ackaert, Oliver, Vanhoutte, Frédéric, Verpoorten, Nathalie, Buelens, Annemie, Lachau-Durand, Sophie, Lammens, Lieve, Hoetelmans, Richard, Van Loock, Marnix, Herrera-Taracena, Guillermo
Publicado 2023

Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK‐1 Inhibitor, After Short‐Term Treatment of Rheumatoid Arthritis: Results of Two Randomized P...

por Vanhoutte, Frédéric, Mazur, Minodora, Voloshyn, Oleksandr, Stanislavchuk, Mykola, Van der Aa, Annegret, Namour, Florence, Galien, René, Meuleners, Luc, van 't Klooster, Gerben
Publicado 2017

Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis

por Berliba, Elina, Bogus, Maxim, Vanhoutte, Frédéric, Berghmans, Pieter-Jan, Good, Steven S., Moussa, Adel, Pietropaolo, Keith, Murphy, Robert L., Zhou, Xiao-Jian, Sommadossi, Jean-Pierre
Publicado 2019

Pharmacokinetics and Pharmacodynamics of Garetosmab (Anti‐Activin A): Results From a First‐in‐Human Phase 1 Study

por Vanhoutte, Frédéric, Liang, Su, Ruddy, Marcella, Zhao, An, Drewery, Tiera, Wang, Yuhuan, DelGizzi, Richard, Forleo‐Neto, Eduardo, Rajadhyaksha, Manoj, Herman, Gary, Davis, John D.
Publicado 2020

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignanci...

por Cirkel, Geert A., Kerklaan, Bojana Milojkovic, Vanhoutte, Frédéric, der Aa, Annegret Van, Lorenzon, Giocondo, Namour, Florence, Pujuguet, Philippe, Darquenne, Sophie, de Vos, Filip Y. F., Snijders, Tom J., Voest, Emile E., Schellens, Jan H. M., Lolkema, Martijn P.
Publicado 2016

Safety and immunogenicity of the measles vector-based SARS-CoV-2 vaccine candidate, V591, in adults: results from a phase 1/2 randomised, double-blind, placebo-controlled, dose-ran...

por Vanhoutte, Frédéric, Liu, Wen, Wiedmann, Richard T., Haspeslagh, Liesbeth, Cao, Xin, Boundy, Keith, Aliprantis, Antonios, Davila, Michelle, Hartzel, Jonathan, Li, Jianing, McGuire, Mac, Ramsauer, Katrin, Tomberger, Yvonne, Tschismarov, Roland, Brown, Deborah D., Xu, Weifeng, Sachs, Jeffrey R., Russell, Kevin, Stoch, S. Aubrey, Lai, Eseng
Publicado 2022

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

por Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng, Lanning, Christine L., Lee, Anita Y.H., Li, Li, Nair, Anilkumar G., O’Neill, Edward A., Stoch, S. Aubrey, Thaisrivongs, David A., Tucker, Thomas J., Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P., Volckaert, Bram, Wolford, Dennis G., Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J., Walji, Abbas M., Wood, Harold B.
Publicado 2023