Single-channel Properties of Human Na(V)1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

por Vanoye, Carlos G., Lossin, Christoph, Rhodes, Thomas H., George, Alfred L.
Publicado 2006

Mechanism of sodium channel Na(V)1.9 potentiation by G-protein signaling

por Vanoye, Carlos G., Kunic, Jennifer D., Ehring, George R., George, Alfred L.
Publicado 2013

Personalized Biochemistry and Biophysics

por Kroncke, Brett M., Vanoye, Carlos G., Meiler, Jens, George, Alfred L., Sanders, Charles R.
Publicado 2015

Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy

por Calhoun, Jeffrey D., Vanoye, Carlos G., Kok, Fernando, George, Alfred L., Kearney, Jennifer A.
Publicado 2017

Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy

por Gertler, Tracy S., Thompson, Christopher H., Vanoye, Carlos G., Millichap, John J., George, Alfred L.
Publicado 2019

Predicting the functional impact of KCNQ1 variants with artificial neural networks

por Phul, Saksham, Kuenze, Georg, Vanoye, Carlos G., Sanders, Charles R., George, Alfred L., Meiler, Jens
Publicado 2022

Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

por Brewer, Kathryn R., Kuenze, Georg, Vanoye, Carlos G., George, Alfred L., Meiler, Jens, Sanders, Charles R.
Publicado 2020

Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits

por Vanoye, Carlos G., Welch, Richard C., Daniels, Melissa A., Manderfield, Lauren J., Tapper, Andrew R., Sanders, Charles R., George, Alfred L.
Publicado 2009

Disease-linked supertrafficking of a potassium channel

por Huang, Hui, Chamness, Laura M., Vanoye, Carlos G., Kuenze, Georg, Meiler, Jens, George, Alfred L., Schlebach, Jonathan Patrick, Sanders, Charles R.
Publicado 2021

Allelic Complexity in Long QT Syndrome: A Family-Case Study

por Zullo, Alberto, Frisso, Giulia, Detta, Nicola, Sarubbi, Berardo, Romeo, Emanuele, Cordella, Angela, Vanoye, Carlos G., Calabrò, Raffaele, George, Alfred L., Salvatore, Francesco
Publicado 2017

Epilepsy-associated SCN2A (Na(V)1.2) Variants Exhibit Diverse and Complex Functional Properties

por Thompson, Christopher H., Potet, Franck, Abramova, Tatiana V., DeKeyser, Jean-Marc, Ghabra, Nora F., Vanoye, Carlos G., Millichap, John, George, Alfred L.
Publicado 2023

Epilepsy-associated SCN2A (Na(V)1.2) variants exhibit diverse and complex functional properties

por Thompson, Christopher H., Potet, Franck, Abramova, Tatiana V., DeKeyser, Jean-Marc, Ghabra, Nora F., Vanoye, Carlos G., Millichap, John J., George, Alfred L.
Publicado 2023

Upgraded molecular models of the human KCNQ1 potassium channel

por Kuenze, Georg, Duran, Amanda M., Woods, Hope, Brewer, Kathryn R., McDonald, Eli Fritz, Vanoye, Carlos G., George, Alfred L., Sanders, Charles R., Meiler, Jens
Publicado 2019

Purification and Structural Study of the Voltage-Sensor Domain of the Human KCNQ1 Potassium Ion Channel

por Peng, Dungeng, Kim, Ji-Hun, Kroncke, Brett M., Law, Cheryl L., Xia, Yan, Droege, Kristin D., Van Horn, Wade D., Vanoye, Carlos G., Sanders, Charles R.
Publicado 2014

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

por Huang, Hui, Kuenze, Georg, Smith, Jarrod A., Taylor, Keenan C., Duran, Amanda M., Hadziselimovic, Arina, Meiler, Jens, Vanoye, Carlos G., George, Alfred L., Sanders, Charles R.
Publicado 2018

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

por Kuenze, Georg, Vanoye, Carlos G, Desai, Reshma R, Adusumilli, Sneha, Brewer, Kathryn R, Woods, Hope, McDonald, Eli F, Sanders, Charles R, George, Alfred L, Meiler, Jens
Publicado 2020

High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity

por Vanoye, Carlos G., Desai, Reshma R., Ji, Zhigang, Adusumilli, Sneha, Jairam, Nirvani, Ghabra, Nora, Joshi, Nishtha, Fitch, Eryn, Helbig, Katherine L., McKnight, Dianalee, Lindy, Amanda S., Zou, Fanggeng, Helbig, Ingo, Cooper, Edward C., George, Alfred L.
Publicado 2022

Structural basis for KCNE3 modulation of potassium recycling in epithelia

por Kroncke, Brett M., Van Horn, Wade D., Smith, Jarrod, Kang, CongBao, Welch, Richard C., Song, Yuanli, Nannemann, David P., Taylor, Keenan C., Sisco, Nicholas J., George, Alfred L., Meiler, Jens, Vanoye, Carlos G., Sanders, Charles R.
Publicado 2016

Dyshomeostatic modulation of Ca(2+)-activated K(+) channels in a human neuronal model of KCNQ2 encephalopathy

por Simkin, Dina, Marshall, Kelly A, Vanoye, Carlos G, Desai, Reshma R, Bustos, Bernabe I, Piyevsky, Brandon N, Ortega, Juan A, Forrest, Marc, Robertson, Gabriella L, Penzes, Peter, Laux, Linda C, Lubbe, Steven J, Millichap, John J, George, Alfred L, Kiskinis, Evangelos
Publicado 2021