Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies

por Vardon, Ashley, Dandapani, Madhumita, Cheng, Daryl, Cheng, Paul, De Santo, Carmela, Mussai, Francis
Publicado 2017

HGG-07. RADIATION INDUCED SENESCENCE IN DIFFUSE INTRINSIC PONTINE GLIOMA CELLS REVEALS SELECTIVE VULNERABILITY TO BCL-XL INHIBITION

por Vardon, Ashley, Guiho, Romain, Carvalho, Diana, Jones, Chris, Hargrave, Darren, Martinez-Barbera, Juan-Pedro
Publicado 2021

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100

por De Santo, Carmela, Booth, Sarah, Vardon, Ashley, Cousins, Antony, Tubb, Vanessa, Perry, Tracey, Noyvert, Boris, Beggs, Andrew, Ng, Margaret, Halsey, Christina, Kearns, Pamela, Cheng, Paul, Mussai, Francis
Publicado 2017

DIPG-46. Radiation induced senescence in diffuse intrinsic pontine glioma cells reveals selective vulnerability to Bcl-XL inhibition

por Vardon, Ashley, Guiho, Romain, Carvalho, Diana, Boult, Jessica, Carter, Rebecca, Grabovska, Yura, Mackay, Alan, Zheng, Guangrong, Zhou, Daohong, Hiley, Crispin, Lythgoe, Mark, Jones, Chris, Hargrave, Darren, Martinez-, Juan-Pedro
Publicado 2022

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment

por Panetti, Silvia, McJannett, Nicola, Fultang, Livingstone, Booth, Sarah, Gneo, Luciana, Scarpa, Ugo, Smith, Charles, Vardon, Ashley, Vettore, Lisa, Whalley, Celina, Pan, Yi, Várnai, Csilla, Endou, Hitoshi, Barlow, Jonathan, Tennant, Daniel, Beggs, Andrew, Mussai, Francis, De Santo, Carmela
Publicado 2022