New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

por Carpintero-Fernandez, Paula, Varela-Eirin, Marta, Lacetera, Alessandra, Gago-Fuentes, Raquel, Fonseca, Eduardo, Martin-Santamaria, Sonsoles, Mayan, Maria D.
Publicado 2020

The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes

por Gago-Fuentes, Raquel, Bechberger, John F., Varela-Eirin, Marta, Varela-Vazquez, Adrian, Acea, Benigno, Fonseca, Eduardo, Naus, Christian C., Mayan, Maria D.
Publicado 2016

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

por Wang, Boshi, Varela‐Eirin, Marta, Brandenburg, Simone M, Hernandez‐Segura, Alejandra, van Vliet, Thijmen, Jongbloed, Elisabeth M, Wilting, Saskia M, Ohtani, Naoko, Jager, Agnes, Demaria, Marco
Publicado 2022

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

por Varela-Eirín, Marta, Varela-Vázquez, Adrián, Guitián-Caamaño, Amanda, Paíno, Carlos Luis, Mato, Virginia, Largo, Raquel, Aasen, Trond, Tabernero, Arantxa, Fonseca, Eduardo, Kandouz, Mustapha, Caeiro, José Ramón, Blanco, Alfonso, Mayán, María D.
Publicado 2018

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis

por Varela-Eirín, Marta, Carpintero-Fernández, Paula, Sánchez-Temprano, Agustín, Varela-Vázquez, Adrián, Paíno, Carlos Luis, Casado-Díaz, Antonio, Continente, Alfonso Calañas, Mato, Virginia, Fonseca, Eduardo, Kandouz, Mustapha, Blanco, Alfonso, Caeiro, José Ramón, Mayán, María D.
Publicado 2020

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

por Varela-Eirín, Marta, Carpintero-Fernández, Paula, Guitián-Caamaño, Amanda, Varela-Vázquez, Adrián, García-Yuste, Alejandro, Sánchez-Temprano, Agustín, Bravo-López, Susana B., Yañez-Cabanas, José, Fonseca, Eduardo, Largo, Raquel, Mobasheri, Ali, Caeiro, José Ramón, Mayán, María D.
Publicado 2022