A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy

por Varn, Frederick S., Wang, Yue, Cheng, Chao
Publicado 2018

Systematic analysis of hematopoietic gene expression profiles for prognostic prediction in acute myeloid leukemia

por Varn, Frederick S., Andrews, Erik H., Cheng, Chao
Publicado 2015

Regulators Associated with Clinical Outcomes Revealed by DNA Methylation Data in Breast Cancer

por Ung, Matthew H., Varn, Frederick S., Lou, Shaoke, Cheng, Chao
Publicado 2015

Integrative analysis of survival-associated gene sets in breast cancer

por Varn, Frederick S, Ung, Matthew H, Lou, Shao Ke, Cheng, Chao
Publicado 2015

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

por Varn, Frederick S., Andrews, Erik H., Mullins, David W., Cheng, Chao
Publicado 2016

Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis

por Ung, Matthew H., Wang, George L., Varn, Frederick S., Cheng, Chao
Publicado 2016

Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy

por Varn, Frederick S., Tafe, Laura J., Amos, Christopher I., Cheng, Chao
Publicado 2018

The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients

por Mark, Kenneth M. K., Varn, Frederick S., Ung, Matthew H., Qian, Feng, Cheng, Chao
Publicado 2017

Whole Transcriptome Signature for Prognostic Prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer

por Schaafsma, Evelien, Zhao, Yanding, Wang, Yue, Varn, Frederick S., Zhu, Kenneth, Yang, Huan, Cheng, Chao
Publicado 2020

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

por Zhao, Yanding, Carter, Robert, Natarajan, Sivaraman, Varn, Frederick S., Compton, Duane A., Gawad, Charles, Cheng, Chao, Godek, Kristina M.
Publicado 2019

OTEH-10. Evolutionary trajectory of epigenomic of gliomas

por Malta, Tathiane, Sabedot, Thais, Datta, Indrani, Varn, Frederick, Castro, AnaValeria, Garofano, Luciano, Verhaak, Roel, Iavarone, Antonio, Poisson, Laila, Noushmehr, Houtan
Publicado 2021

Perspective of mesenchymal transformation in glioblastoma

por Kim, Yona, Varn, Frederick S., Park, Sung-Hye, Yoon, Byung Woo, Park, Hye Ran, Lee, Charles, Verhaak, Roel G. W., Paek, Sun Ha
Publicado 2021

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in cancer patients

por Kocakavuk, Emre, Anderson, Kevin J., Varn, Frederick S., Johnson, Kevin C., Amin, Samirkumar B., Sulman, Erik. P., Lolkema, Martijn P., Barthel, Floris P., Verhaak, Roel G.W.
Publicado 2021

OMRT-3. Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

por Varn, Frederick, Johnson, Kevin, Barthel, Floris, Kim, Hoon, Wade, Taylor, Malta, Tathiane, Sabedot, Thais, Lodha, Disha, Ajaib, Shoaib, Ahmed, Nazia, Garofano, Luciano, D’Angelo, Fulvio, Stead, Lucy, Poisson, Laila, Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel
Publicado 2021

Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma

por Yeo, Alan T., Shah, Rushil, Aliazis, Konstantinos, Pal, Rinku, Xu, Tuoye, Zhang, Piyan, Rawal, Shruti, Rose, Christopher M., Varn, Frederick S., Appleman, Vicky A., Yoon, Joon, Varma, Hemant, Gygi, Steven P., Verhaak, Roel G.W., Boussiotis, Vassiliki A., Charest, Al
Publicado 2023

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data

por Ajaib, Shoaib, Lodha, Disha, Pollock, Steven, Hemmings, Gemma, Finetti, Martina A, Gusnanto, Arief, Chakrabarty, Aruna, Ismail, Azzam, Wilson, Erica, Varn, Frederick S, Hunter, Bethany, Filby, Andrew, Brockman, Asa A, McDonald, David, Verhaak, Roel G W, Ihrie, Rebecca A, Stead, Lucy F
Publicado 2023

Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

por Shee, Kevin, Yang, Wei, Hinds, John W., Hampsch, Riley A., Varn, Frederick S., Traphagen, Nicole A., Patel, Kishan, Cheng, Chao, Jenkins, Nicole P., Kettenbach, Arminja N., Demidenko, Eugene, Owens, Philip, Faber, Anthony C., Golub, Todd R., Straussman, Ravid, Miller, Todd W.
Publicado 2018

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

por Johnson, Kevin C., Anderson, Kevin J., Courtois, Elise T., Gujar, Amit D., Barthel, Floris P., Varn, Frederick S., Luo, Diane, Seignon, Martine, Yi, Eunhee, Kim, Hoon, Estecio, Marcos RH, Zhao, Dacheng, Tang, Ming, Navin, Nicholas E., Maurya, Rahul, Ngan, Chew Yee, Verburg, Niels, de Witt Hamer, Philip C, Bulsara, Ketan, Samuels, Michael L., Das, Sunit, Robson, Paul, Verhaak, Roel GW
Publicado 2021

Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression

por Najem, Hinda, Ott, Martina, Kassab, Cynthia, Rao, Arvind, Rao, Ganesh, Marisetty, Anantha, Sonabend, Adam M., Horbinski, Craig, Verhaak, Roel, Shankar, Anand, Krishnan, Santhoshi N., Varn, Frederick S., Arrieta, Víctor A., Gupta, Pravesh, Ferguson, Sherise D., Huse, Jason T., Fuller, Gregory N., Long, James P., Winkowski, Daniel E., Freiberg, Ben A., James, Charles David, Platanias, Leonidas C., Lesniak, Maciej S., Burks, Jared K., Heimberger, Amy B.
Publicado 2022

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

por Gromeier, Matthias, Brown, Michael C., Zhang, Gao, Lin, Xiang, Chen, Yeqing, Wei, Zhi, Beaubier, Nike, Yan, Hai, He, Yiping, Desjardins, Annick, Herndon, James E., Varn, Frederick S., Verhaak, Roel G., Zhao, Junfei, Bolognesi, Dani P., Friedman, Allan H., Friedman, Henry S., McSherry, Frances, Muscat, Andrea M., Lipp, Eric S., Nair, Smita K., Khasraw, Mustafa, Peters, Katherine B., Randazzo, Dina, Sampson, John H., McLendon, Roger E., Bigner, Darell D., Ashley, David M.
Publicado 2021