Mouse model hints at pharmacogenomic strategies for stroke treatment in patients possessing a risk variant

por Vaughan, Douglas E.
Publicado 2023

Molecular and physiological manifestations and measurement of aging in humans

por Khan, Sadiya S., Singer, Benjamin D., Vaughan, Douglas E.
Publicado 2017

Global Gene Expression Profiling in PAI-1 Knockout Murine Heart and Kidney: Molecular Basis of Cardiac-Selective Fibrosis

por Ghosh, Asish K., Murphy, Sheila B., Kishore, Raj, Vaughan, Douglas E.
Publicado 2013

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

por Henkel, Anne S., Khan, Sadiya S., Olivares, Shantel, Miyata, Toshio, Vaughan, Douglas E.
Publicado 2018

Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

por Sillen, Machteld, Miyata, Toshio, Vaughan, Douglas E., Strelkov, Sergei V., Declerck, Paul J.
Publicado 2021

PAI-1 is a critical regulator of FGF23 homeostasis

por Eren, Mesut, Place, Aaron T., Thomas, Paul M., Flevaris, Panagiotis, Miyata, Toshio, Vaughan, Douglas E.
Publicado 2017

Acetyltransferase p300 inhibitor reverses hypertension‐induced cardiac fibrosis

por Rai, Rahul, Sun, Tianjiao, Ramirez, Veronica, Lux, Elizabeth, Eren, Mesut, Vaughan, Douglas E., Ghosh, Asish K.
Publicado 2019

Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis

por Pelisch, Nicolas, Dan, Takashi, Ichimura, Atsuhiko, Sekiguchi, Hiroki, Vaughan, Douglas E., van Ypersele de Strihou, Charles, Miyata, Toshio
Publicado 2015

DNA Damage: A Main Determinant of Vascular Aging

por Bautista-Niño, Paula K., Portilla-Fernandez, Eliana, Vaughan, Douglas E., Danser, A. H. Jan, Roks, Anton J. M.
Publicado 2016

A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence

por Ghosh, Asish K., Rai, Rahul, Park, Kitae E., Eren, Mesut, Miyata, Toshio, Wilsbacher, Lisa D., Vaughan, Douglas E.
Publicado 2016

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

por Yahata, Takashi, Ibrahim, Abd Aziz, Hirano, Ken-ichi, Muguruma, Yukari, Naka, Kazuhito, Hozumi, Katsuto, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
Publicado 2020

Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

por Boe, Amanda E., Eren, Mesut, Morales-Nebreda, Luisa, Murphy, Sheila B., Budinger, G. R. Scott, Mutlu, Gökhan M., Miyata, Toshio, Vaughan, Douglas E.
Publicado 2015

Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM(2.5)()

por Ghosh, Asish K., Soberanes, Saul, Lux, Elizabeth, Shang, Meng, Aillon, Raul Piseaux, Eren, Mesut, Budinger, G.R. Scott, Miyata, Toshio, Vaughan, Douglas E.
Publicado 2021

A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis

por Rose, Shawn, Eren, Mesut, Murphy, Sheila, Zhang, Heng, Thaxton, Colby Shad, Chowaniec, Jaime, Waters, Emily A, Meade, Thomas J, Vaughan, Douglas E, Perlman, Harris
Publicado 2013

Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population

por White, Marquitta J., Kodaman, Nuri M., Harder, Reed H., Asselbergs, Folkert W., Vaughan, Douglas E., Brown, Nancy J., Moore, Jason H., Williams, Scott M.
Publicado 2015

Generation of human iPSCs from urine derived cells of patient with a novel heterozygous PAI-1 mutation

por Afzal, Muhammad Zeeshan, Gartz, Melanie, Klyachko, Ekaterina A., Khan, Sadiya Sana, Shah, Sanjiv J., Gupta, Sweta, Shapiro, Amy D., Vaughan, Douglas E., Strande, Jennifer L.
Publicado 2016

An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene Interactions on risk of myocardial infarction: The importance of...

por Coffey, Christopher S, Hebert, Patricia R, Ritchie, Marylyn D, Krumholz, Harlan M, Gaziano, J Michael, Ridker, Paul M, Brown, Nancy J, Vaughan, Douglas E, Moore, Jason H
Publicado 2004

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

por Rai, Rahul, Verma, Suresh K., Kim, David, Ramirez, Veronica, Lux, Elizabeth, Li, Chengjin, Sahoo, Susmita, Wilsbacher, Lisa D., Vaughan, Douglas E., Quaggin, Susan E., Ghosh, Asish K.
Publicado 2017

Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status

por Kim, Kyeezu, Joyce, Brian T., Nannini, Drew R., Zheng, Yinan, Gordon-Larsen, Penny, Shikany, James M., Lloyd-Jones, Donald M., Hu, Ming, Nieuwenhuijsen, Mark J., Vaughan, Douglas E., Zhang, Kai, Hou, Lifang
Publicado 2023

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

por Archer, Amy M., Saber, Rana, Rose, Shawn, Shaffer, Alexander, Misharin, Alexander V., Tsai, FuNien, Haines III, G. Kenneth, Dominguez, Salina, Eren, Mesut, Vaughan, Douglas E., Cuda, Carla M., Perlman, Harris
Publicado 2016