Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b(5) Activit...

por Indra, Radek, Vavrová, Katarína, Pompach, Petr, Heger, Zbyněk, Hodek, Petr
Publicado 2020

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation

por Indra, Radek, Pompach, Petr, Martínek, Václav, Takácsová, Paulína, Vavrová, Katarína, Heger, Zbyněk, Adam, Vojtěch, Eckschlager, Tomáš, Kopečková, Kateřina, Arlt, Volker Manfred, Stiborová, Marie
Publicado 2019