Growth differentiation factor 15 as a potential therapeutic for treating obesity

por Hale, Clarence, Véniant, Murielle M.
Publicado 2020

GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance

por Wang, Jinghong, Pan, Zheng, Baribault, Helene, Chui, Danny, Gundel, Caroline, Véniant, Murielle
Publicado 2016

FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

por Véniant, Murielle M., Hale, Clarence, Helmering, Joan, Chen, Michelle M., Stanislaus, Shanaka, Busby, Jim, Vonderfecht, Steven, Xu, Jing, Lloyd, David J.
Publicado 2012

A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face

por Lloyd, David J., Helmering, Joan, Kaufman, Stephen A., Turk, James, Silva, Matt, Vasquez, Sergio, Weinstein, David, Johnston, Brad, Hale, Clarence, Véniant, Murielle M.
Publicado 2011

Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

por Anderson, Abraham A, Helmering, Joan, Juan, Todd, Li, Chi-Ming, McCormick, Jocelyn, Graham, Melissa, Baker, Daniel M, Damore, Michael A, Véniant, Murielle M, Lloyd, David J
Publicado 2009

The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15

por Stolina, Marina, Luo, Xin, Dwyer, Denise, Han, Chun-Ya, Chen, Rhonda, Zhang, Ying, Xiong, YuMei, Chen, Yinhong, Yin, Jun, Shkumatov, Artem, Ason, Brandon, Hale, Clarence, Véniant, Murielle M.
Publicado 2020

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

por Killion, Elizabeth A., Chen, Michelle, Falsey, James R., Sivits, Glenn, Hager, Todd, Atangan, Larissa, Helmering, Joan, Lee, Jae, Li, Hongyan, Wu, Bin, Cheng, Yuan, Véniant, Murielle M., Lloyd, David J.
Publicado 2020

Characterization of a Novel Glucokinase Activator in Rat and Mouse Models

por Lu, Min, Li, Pingping, Bandyopadhyay, Gautam, Lagakos, William, DeWolf, Walter E., Alford, Taylor, Chicarelli, Mark Joseph, Williams, Lance, Anderson, Deborah A., Baer, Brian R., McVean, Maralee, Conn, Marion, Véniant, Murielle M., Coward, Peter
Publicado 2014

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

por Xu, Jing, Lloyd, David J., Hale, Clarence, Stanislaus, Shanaka, Chen, Michelle, Sivits, Glenn, Vonderfecht, Steven, Hecht, Randy, Li, Yue-Sheng, Lindberg, Richard A., Chen, Jin-Long, Jung, Dae Young, Zhang, Zhiyou, Ko, Hwi Jin, Kim, Jason K., Véniant, Murielle M.
Publicado 2009

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

por Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R., Alba, Benjamin M., Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W., Véniant, Murielle M., Li, Yang
Publicado 2013

A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice

por Helmering, Joan, Juan, Todd, Li, Chi Ming, Chhoa, Mark, Baron, Will, Gyuris, Tibor, Richards, William G, Turk, James R, Lawrence, Jeff, Cosgrove, Patrick A, Busby, Jim, Kim, Ki Won, Kaufman, Stephen A, Cummings, Connie, Carlson, George, Véniant, Murielle M, Lloyd, David J
Publicado 2014

GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys

por Lu, Shu-Chen, Chen, Michelle, Atangan, Larissa, Killion, Elizabeth A., Komorowski, Renee, Cheng, Yuan, Netirojjanakul, Chawita, Falsey, James R., Stolina, Marina, Dwyer, Denise, Hale, Clarence, Stanislaus, Shanaka, Hager, Todd, Thomas, Veena A., Harrold, John M., Lloyd, David J., Véniant, Murielle M.
Publicado 2021

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

por Min, Xiaoshan, Yie, Junming, Wang, Jinghong, Chung, Ben C., Huang, Ching-Shin, Xu, Haoda, Yang, Jie, Deng, Liying, Lin, Joanne, Chen, Qing, Abbott, Christina M., Gundel, Caroline, Thibault, Stephen A., Meng, Tina, Bates, Darren L., Lloyd, David J., Véniant, Murielle M., Wang, Zhulun
Publicado 2020

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

por Hecht, Randy, Li, Yue-Sheng, Sun, Jeonghoon, Belouski, Ed, Hall, Michael, Hager, Todd, Yie, Junming, Wang, Wei, Winters, Dwight, Smith, Stephen, Spahr, Chris, Tam, Lei-Ting, Shen, Zhongnan, Stanislaus, Shanaka, Chinookoswong, Narumol, Lau, Yvonne, Sickmier, Allen, Michaels, Mark Leo, Boone, Thomas, Véniant, Murielle M., Xu, Jing
Publicado 2012

Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

por Ge, Hongfei, Gardner, Jonitha, Wu, Xiaosu, Rulifson, Ingrid, Wang, Jinghong, Xiong, Yumei, Ye, Jingjing, Belouski, Edward, Cao, Ping, Tang, Jie, Lee, Ki Jeong, Coberly, Suzanne, Wu, Xinle, Gupte, Jamila, Miao, Lynn, Yang, Li, Nguyen, Natalie, Shan, Bei, Yeh, Wen-Chen, Véniant, Murielle M., Li, Yang, Baribault, Helene
Publicado 2015

5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

por Kohn, Todd J., Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E., Kraser, Christopher F., Hinklin, Ronald J., Boys, Mark L., Medina, Julio C., Houze, Jonathan, Dransfield, Paul, Coward, Peter
Publicado 2016