Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons

por Gegg, Matthew E, Verona, Guglielmo, Schapira, Anthony H V
Publicado 2020

Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord

por Izco, Maria, Schleef, Martin, Schmeer, Marco, Carlos, Estefania, Verona, Guglielmo, Alvarez-Erviti, Lydia
Publicado 2023

L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils

por Migdalska‐Richards, Anna, Wegrzynowicz, Michal, Harrison, Ian F., Verona, Guglielmo, Bellotti, Vittorio, Spillantini, Maria Grazia, Schapira, Anthony H. V.
Publicado 2020

Calcium Binds to Transthyretin with Low Affinity

por Cantarutti, Cristina, Mimmi, Maria Chiara, Verona, Guglielmo, Mandaliti, Walter, Taylor, Graham W., Mangione, P. Patrizia, Giorgetti, Sofia, Bellotti, Vittorio, Corazza, Alessandra
Publicado 2022

Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein

por Moura, Alexandra, Nocerino, Paola, Gilbertson, Janet A., Rendell, Nigel B., Mangione, P. Patrizia, Verona, Guglielmo, Rowczenio, Dorota, Gillmore, Julian D., Taylor, Graham W., Bellotti, Vittorio, Canetti, Diana
Publicado 2020

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

por Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher A., Mangione, P. Patrizia, Bingham, Ryan, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W., Pepys, Mark B., Christodoulou, John, Bellotti, Vittorio
Publicado 2019

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

por Verona, Guglielmo, Mangione, P. Patrizia, Raimondi, Sara, Giorgetti, Sofia, Faravelli, Giulia, Porcari, Riccardo, Corazza, Alessandra, Gillmore, Julian D., Hawkins, Philip N., Pepys, Mark B., Taylor, Graham W., Bellotti, Vittorio
Publicado 2017

Human wild‐type and D76N β(2)‐microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans

por Raimondi, Sara, Faravelli, Giulia, Nocerino, Paola, Mondani, Valentina, Baruffaldi, Alma, Marchese, Loredana, Mimmi, Maria Chiara, Canetti, Diana, Verona, Guglielmo, Caterino, Marianna, Ruoppolo, Margherita, Mangione, P. Patrizia, Bellotti, Vittorio, Lavatelli, Francesca, Giorgetti, Sofia
Publicado 2023

Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms

por Faravelli, Giulia, Mondani, Valentina, Mangione, P. Patrizia, Raimondi, Sara, Marchese, Loredana, Lavatelli, Francesca, Stoppini, Monica, Corazza, Alessandra, Canetti, Diana, Verona, Guglielmo, Obici, Laura, Taylor, Graham W., Gillmore, Julian D., Giorgetti, Sofia, Bellotti, Vittorio
Publicado 2022

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

por Porcari, Riccardo, Proukakis, Christos, Waudby, Christopher A., Bolognesi, Benedetta, Mangione, P. Patrizia, Paton, Jack F. S., Mullin, Stephen, Cabrita, Lisa D., Penco, Amanda, Relini, Annalisa, Verona, Guglielmo, Vendruscolo, Michele, Stoppini, Monica, Tartaglia, Gian Gaetano, Camilloni, Carlo, Christodoulou, John, Schapira, Anthony H. V., Bellotti, Vittorio
Publicado 2015

Clinical ApoA‐IV amyloid is associated with fibrillogenic signal sequence

por Canetti, Diana, Nocerino, Paola, Rendell, Nigel B, Botcher, Nicola, Gilbertson, Janet A, Blanco, Angel, Rowczenio, Dorota, Morelli, Alessandra, Mangione, P Patrizia, Corazza, Alessandra, Verona, Guglielmo, Giorgetti, Sofia, Marchese, Loredana, Westermark, Per, Hawkins, Philip N, Gillmore, Julian D, Bellotti, Vittorio, Taylor, Graham W
Publicado 2021

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

por Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier-Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio
Publicado 2015

Plasminogen activation triggers transthyretin amyloidogenesis in vitro

por Mangione, P. Patrizia, Verona, Guglielmo, Corazza, Alessandra, Marcoux, Julien, Canetti, Diana, Giorgetti, Sofia, Raimondi, Sara, Stoppini, Monica, Esposito, Marilena, Relini, Annalisa, Canale, Claudio, Valli, Maurizia, Marchese, Loredana, Faravelli, Giulia, Obici, Laura, Hawkins, Philip N., Taylor, Graham W., Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio
Publicado 2018

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis

por Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul
Publicado 2021

A specific nanobody prevents amyloidogenesis of D76N β(2)-microglobulin in vitro and modifies its tissue distribution in vivo

por Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio
Publicado 2017

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

por Valleix, Sophie, Verona, Guglielmo, Jourde-Chiche, Noémie, Nédelec, Brigitte, Mangione, P. Patrizia, Bridoux, Frank, Mangé, Alain, Dogan, Ahmet, Goujon, Jean-Michel, Lhomme, Marie, Dauteuille, Carolane, Chabert, Michèle, Porcari, Riccardo, Waudby, Christopher A., Relini, Annalisa, Talmud, Philippa J., Kovrov, Oleg, Olivecrona, Gunilla, Stoppini, Monica, Christodoulou, John, Hawkins, Philip N., Grateau, Gilles, Delpech, Marc, Kontush, Anatol, Gillmore, Julian D., Kalopissis, Athina D., Bellotti, Vittorio
Publicado 2016