Key Inflammatory Processes in Human NASH Are Reflected in Ldlr(−/−).Leiden Mice: A Translational Gene Profiling Study

por Morrison, Martine C., Kleemann, Robert, van Koppen, Arianne, Hanemaaijer, Roeland, Verschuren, Lars
Publicado 2018

Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters

por Kelder, Thomas, Verschuren, Lars, van Ommen, Ben, van Gool, Alain J, Radonjic, Marijana
Publicado 2014

Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice

por Salic, Kanita, Kleemann, Robert, Wilkins-Port, Cynthia, McNulty, John, Verschuren, Lars, Palmer, Melissa
Publicado 2019

Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients

por Abe, Naomichi, Kato, Sayuka, Tsuchida, Takuma, Sugimoto, Kanami, Saito, Ryuta, Verschuren, Lars, Kleemann, Robert, Oka, Kozo
Publicado 2019

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

por Verschuren, Lars, Wielinga, Peter Y, Kelder, Thomas, Radonjic, Marijana, Salic, Kanita, Kleemann, Robert, van Ommen, Ben, Kooistra, Teake
Publicado 2014

Unraveling the Transcriptional Dynamics of NASH Pathogenesis Affecting Atherosclerosis

por van den Hoek, Anita M., Özsezen, Serdar, Caspers, Martien P. M., van Koppen, Arianne, Hanemaaijer, Roeland, Verschuren, Lars
Publicado 2022

A Dietary Mixture Containing Fish Oil, Resveratrol, Lycopene, Catechins, and Vitamins E and C Reduces Atherosclerosis in Transgenic Mice(2)

por Verschuren, Lars, Wielinga, Peter Y., van Duyvenvoorde, Wim, Tijani, Samira, Toet, Karin, van Ommen, Ben, Kooistra, Teake, Kleemann, Robert
Publicado 2011

Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice

por Mulder, Petra, Morrison, Martine C., Verschuren, Lars, Liang, Wen, van Bockel, J. Hajo, Kooistra, Teake, Wielinga, Peter Y., Kleemann, Robert
Publicado 2016

Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men

por van den Hoek, Anita M., Verschuren, Lars, Caspers, Martien P. M., Worms, Nicole, Menke, Aswin L., Princen, Hans M. G.
Publicado 2021

Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model

por Van Loy, Tom, De Jonghe, Steven, Castermans, Karolien, Dheedene, Wouter, Stoop, Reinout, Verschuren, Lars, Versele, Matthias, Chaltin, Patrick, Luttun, Aernout, Schols, Dominique
Publicado 2022

A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis

por Kleemann, Robert, Bureeva, Svetlana, Perlina, Ally, Kaput, Jim, Verschuren, Lars, Wielinga, Peter Y, Hurt-Camejo, Eva, Nikolsky, Yuri, van Ommen, Ben, Kooistra, Teake
Publicado 2011

Non-Parenchymal Cells and the Extracellular Matrix in Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease

por van Son, Koen C., Verschuren, Lars, Hanemaaijer, Roeland, Reeves, Helen, Takkenberg, R. Bart, Drenth, Joost P. H., Tushuizen, Maarten E., Holleboom, Adriaan G.
Publicado 2023

Network-Based Selection of Candidate Markers and Assays to Assess the Impact of Oral Immune Interventions on Gut Functions

por Meijerink, Marjolein, van den Broek, Tim J., Dulos, Remon, Garthoff, Jossie, Knippels, Léon, Knipping, Karen, Harthoorn, Lucien, Houben, Geert, Verschuren, Lars, van Bilsen, Jolanda
Publicado 2019

Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in...

por Gart, Eveline, Souto Lima, Everton, Schuren, Frank, de Ruiter, Christa G. F., Attema, Joline, Verschuren, Lars, Keijer, Jaap, Salic, Kanita, Morrison, Martine C., Kleemann, Robert
Publicado 2018

Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice

por Pouwer, Marianne G, Pieterman, Elsbet J, Chang, Shu-Ching, Olsen, Geary W, Caspers, Martien P M, Verschuren, Lars, Jukema, J Wouter, Princen, Hans M G
Publicado 2019

The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model

por Pouwer, Marianne G., Pieterman, Elsbet J., Verschuren, Lars, Caspers, Martien P. M., Kluft, Cornelis, Garcia, Ricardo A., Aman, Jurjan, Jukema, J. Wouter, Princen, Hans M. G.
Publicado 2018

Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis

por Salic, Kanita, Gart, Eveline, Seidel, Florine, Verschuren, Lars, Caspers, Martien, van Duyvenvoorde, Wim, Wong, Kari E., Keijer, Jaap, Bobeldijk-Pastorova, Ivana, Wielinga, Peter Y., Kleemann, Robert
Publicado 2019

Mechanism-Based Biomarker Prediction for Low-Grade Inflammation in Liver and Adipose Tissue

por van Bilsen, Jolanda H. M., van den Brink, Willem, van den Hoek, Anita M., Dulos, Remon, Caspers, Martien P. M., Kleemann, Robert, Wopereis, Suzan, Verschuren, Lars
Publicado 2021

The Impact of Immune Interventions: A Systems Biology Strategy for Predicting Adverse and Beneficial Immune Effects

por Meijerink, Marjolein, van den Broek, Tim, Dulos, Remon, Neergaard Jacobsen, Lotte, Staudt Kvistgaard, Anne, Garthoff, Jossie, Knippels, Léon, Knipping, Karen, Houben, Geert, Verschuren, Lars, van Bilsen, Jolanda
Publicado 2019

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

por van den Brink, Willem, van Bilsen, Jolanda, Salic, Kanita, Hoevenaars, Femke P. M., Verschuren, Lars, Kleemann, Robert, Bouwman, Jildau, Ronnett, Gabriele V., van Ommen, Ben, Wopereis, Suzan
Publicado 2019