siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs

por Vickers, Timothy A., Crooke, Stanley T.
Publicado 2012

Antisense Oligonucleotides Capable of Promoting Specific Target mRNA Reduction via Competing RNase H1-Dependent and Independent Mechanisms

por Vickers, Timothy A., Crooke, Stanley T.
Publicado 2014

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA

por Vickers, Timothy A., Crooke, Stanley T.
Publicado 2015

Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions

por Vickers, Timothy A., Crooke, Stanley T.
Publicado 2016

U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP

por Vickers, Timothy A., Sabripour, Mahyar, Crooke, Stanley T.
Publicado 2011

Phosphorothioate modified oligonucleotide–protein interactions

por Crooke, Stanley T, Vickers, Timothy A, Liang, Xue-hai
Publicado 2020

Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice

por Liang, Xue-hai, Vickers, Timothy A., Guo, Shuling, Crooke, Stanley T.
Publicado 2011

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1

por Vickers, Timothy A, Rahdar, Meghdad, Prakash, Thazha P, Crooke, Stanley T
Publicado 2019

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

por Vickers, Timothy A., Lima, Walt F., Nichols, Josh G., Crooke, Stanley T.
Publicado 2007

Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

por Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Publicado 2014

Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

por Zhang, Lingdi, Vickers, Timothy A, Sun, Hong, Liang, Xue-hai, Crooke, Stanley T
Publicado 2021

Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency

por Vickers, Timothy A., Freier, Susan M., Bui, Huynh-Hoa, Watt, Andrew, Crooke, Stanley T.
Publicado 2014

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

por Hua, Yimin, Vickers, Timothy A, Baker, Brenda F, Bennett, C. Frank, Krainer, Adrian R
Publicado 2007

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

por Liang, Xue-hai, Nichols, Joshua G, Hsu, Chih-Wei, Vickers, Timothy A, Crooke, Stanley T
Publicado 2019

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

por Vickers, Timothy A., Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Linsley, Peter S., Crooke, Stanley T.
Publicado 2009

NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides

por Zhang, Lingdi, Bernardo, Karla D., Vickers, Timothy A., Tian, Jun, Liang, Xue-hai, Crooke, Stanley T.
Publicado 2022

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

por Shen, Wen, De Hoyos, Cheryl L, Sun, Hong, Vickers, Timothy A, Liang, Xue-hai, Crooke, Stanley T
Publicado 2018

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

por Wang, Shiyu, Allen, Nickolas, Vickers, Timothy A, Revenko, Alexey S, Sun, Hong, Liang, Xue-hai, Crooke, Stanley T
Publicado 2018

Insights into innate immune activation via PS-ASO–protein–TLR9 interactions

por Pollak, Adam J, Zhao, Luyi, Vickers, Timothy A, Huggins, Ian J, Liang, Xue-Hai, Crooke, Stanley T
Publicado 2022

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

por Liang, Xue-hai, Sun, Hong, Hsu, Chih-Wei, Nichols, Joshua G, Vickers, Timothy A, De Hoyos, Cheryl L, Crooke, Stanley T
Publicado 2020