Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

por Vidler, Lewis R., Brown, Nathan, Knapp, Stefan, Hoelder, Swen
Publicado 2012

Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set

por Vidler, Lewis R., Watson, Ian A., Margolis, Brandon J., Cummins, David J., Brunavs, Michael
Publicado 2018

Structure‐Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1

por McGrath, Sally, Tortorici, Marcello, Drouin, Ludovic, Solanki, Savade, Vidler, Lewis, Westwood, Isaac, Gimeson, Peter, Van Montfort, Rob, Hoelder, Swen
Publicado 2017

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

por Vidler, Lewis R., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Martin, Sarah, Tomsett, Michael, Woodward, Hannah, Brown, Nathan, Knapp, Stefan, Hoelder, Swen
Publicado 2013

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

por Darby, John F., Vidler, Lewis R., Simpson, Peter J., Al-Lazikani, Bissan, Matthews, Stephen J., Sharp, Swee Y., Pearl, Laurence H., Hoelder, Swen, Workman, Paul
Publicado 2020

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

por Drouin, Ludovic, McGrath, Sally, Vidler, Lewis R., Chaikuad, Apirat, Monteiro, Octovia, Tallant, Cynthia, Philpott, Martin, Rogers, Catherine, Fedorov, Oleg, Liu, Manjuan, Akhtar, Wasim, Hayes, Angela, Raynaud, Florence, Müller, Susanne, Knapp, Stefan, Hoelder, Swen
Publicado 2015

Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates

por Jones, S. Paul, Firth, James D., Wheldon, Mary C., Atobe, Masakazu, Hubbard, Roderick E., Blakemore, David C., De Fusco, Claudia, Lucas, Simon C. C., Roughley, Stephen D., Vidler, Lewis R., Whatton, Maria Ann, Woolford, Alison J.-A., Wrigley, Gail L., O'Brien, Peter
Publicado 2022

Design and Synthesis of 56 Shape‐Diverse 3D Fragments

por Downes, Thomas D., Jones, S. Paul, Klein, Hanna F., Wheldon, Mary C., Atobe, Masakazu, Bond, Paul S., Firth, James D., Chan, Ngai S., Waddelove, Laura, Hubbard, Roderick E., Blakemore, David C., De Fusco, Claudia, Roughley, Stephen D., Vidler, Lewis R., Whatton, Maria Ann, Woolford, Alison J.‐A., Wrigley, Gail L., O'Brien, Peter
Publicado 2020