Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution

por Meini, María-Rocío, Llarrull, Leticia I., Vila, Alejandro J.
Publicado 2014

Biochemistry of Copper Site Assembly in Heme-Copper Oxidases: A Theme with Variations

por Llases, María-Eugenia, Morgada, Marcos N., Vila, Alejandro J.
Publicado 2019

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

por Palacios, Antonela R., Rossi, María-Agustina, Mahler, Graciela S., Vila, Alejandro J.
Publicado 2020

Host-Specific Enzyme-Substrate Interactions in SPM-1 Metallo-β-Lactamase Are Modulated by Second Sphere Residues

por González, Lisandro J., Moreno, Diego M., Bonomo, Robert A., Vila, Alejandro J.
Publicado 2014

The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

por Mojica, Maria F, Rossi, Maria-Agustina, Vila, Alejandro J, Bonomo, Robert A
Publicado 2022

Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions

por Rossi, Maria-Agustina, Palzkill, Timothy, Almeida, Fabio C L, Vila, Alejandro J
Publicado 2022

Protein determinants of dissemination and host specificity of metallo-β-lactamases

por López, Carolina, Ayala, Juan A., Bonomo, Robert A., González, Lisandro J., Vila, Alejandro J.
Publicado 2019

On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1)

por Martínez, Melina M. B., Bonomo, Robert A., Vila, Alejandro J., Maffía, Paulo C., González, Lisandro J.
Publicado 2021

Membrane-anchoring stabilizes and favors secretion of New Delhi Metallo-β-lactamase

por González, Lisandro J., Bahr, Guillermo, Nakashige, Toshiki G., Nolan, Elizabeth M., Bonomo, Robert A., Vila, Alejandro J.
Publicado 2016

2178. Resistance to Cefepime/Taniborbactam in NDM-1 -Are We Losing the Battle against MDROs?

por Ono, Daisuke, Mojica, Maria F, Bethel, Christopher R, Ishii, Yoshikazu, Moreno, Diego, Vila, Alejandro J, Bonomo, Robert A
Publicado 2023

Metallo-β-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions

por González, Javier M., Meini, María-Rocío, Tomatis, Pablo E., Medrano Martín, Francisco J., Cricco, Julia A., Vila, Alejandro J.
Publicado 2012

Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis

por Espinoza-Cara, Andrés, Zitare, Ulises, Alvarez-Paggi, Damián, Klinke, Sebastián, Otero, Lisandro H., Murgida, Daniel H., Vila, Alejandro J.
Publicado 2018

Cu(A)-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential

por Szuster, Jonathan, Zitare, Ulises A., Castro, María A., Leguto, Alcides J., Morgada, Marcos N., Vila, Alejandro J., Murgida, Daniel H.
Publicado 2020

1437. Biochemical characterization of L1 and L2 β-lactamases from clinical isolates of Stenotrophomonas maltophilia

por Mojica, Maria F, Rutter, Joseph, Taracila, Magdalena A, Papp-Wallce, Krisztina M, Spencer, James, Vila, Alejandro J, Bonomo, Robert A
Publicado 2020

Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products

por Hinchliffe, Philip, Calvopiña, Karina, Rabe, Patrick, Mojica, Maria F., Schofield, Christopher J., Dmitrienko, Gary I., Bonomo, Robert A., Vila, Alejandro J., Spencer, James
Publicado 2023

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

por Zhao, Zhuoran, Shen, Xiayu, Chen, Shuang, Gu, Jing, Wang, Haun, Mojica, Maria F, Samanta, Moumita, Bhowmik, Debsindhu, Vila, Alejandro J, Bonomo, Robert A, Haider, Shozeb
Publicado 2023

The H-NS Regulator Plays a Role in the Stress Induced by Carbapenemase Expression in Acinetobacter baumannii

por Huang, Fanny, Fitchett, Noelle, Razo-Gutierrez, Chelsea, Le, Casin, Martinez, Jasmine, Ra, Grace, Lopez, Carolina, Gonzalez, Lisandro J., Sieira, Rodrigo, Vila, Alejandro J., Bonomo, Robert A., Ramirez, Maria Soledad
Publicado 2020

The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro

por McCann, Cat, Quinteros, Michael, Adelugba, Ifeoluwa, Morgada, Marcos N., Castelblanco, Aida R., Davis, Emily J., Lanzirotti, Antonio, Hainer, Sarah J., Vila, Alejandro J., Navea, Juan G., Padilla-Benavides, Teresita
Publicado 2022

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

por Lisa, María-Natalia, Palacios, Antonela R., Aitha, Mahesh, González, Mariano M., Moreno, Diego M., Crowder, Michael W., Bonomo, Robert A., Spencer, James, Tierney, David L., Llarrull, Leticia I., Vila, Alejandro J.
Publicado 2017

Population Structure, Molecular Epidemiology, and β-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States

por Mojica, Maria F., Rutter, Joseph D., Taracila, Magdalena, Abriata, Luciano A., Fouts, Derrick E., Papp-Wallace, Krisztina M., Walsh, Thomas J., LiPuma, John J., Vila, Alejandro J., Bonomo, Robert A.
Publicado 2019