Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

por Villarreal, Oscar D, Mersaoui, Sofiane Y, Yu, Zhenbao, Masson, Jean-Yves, Richard, Stéphane
Publicado 2020

Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

por Dominici, Claudia, Villarreal, Oscar D, Dort, Junio, Heckel, Emilie, Wang, Yu Chang, Ragoussis, Ioannis, Joyal, Jean-Sebastien, Dumont, Nicolas, Richard, Stéphane
Publicado 2023

PRMT1 loss sensitizes cells to PRMT5 inhibition

por Gao, Guozhen, Zhang, Liang, Villarreal, Oscar D, He, Wei, Su, Dan, Bedford, Ella, Moh, Phoebe, Shen, Jianjun, Shi, Xiaobing, Bedford, Mark T, Xu, Han
Publicado 2019

De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens

por He, Wei, Zhang, Liang, Villarreal, Oscar D., Fu, Rongjie, Bedford, Ella, Dou, Jingzhuang, Patel, Anish Y., Bedford, Mark T., Shi, Xiaobing, Chen, Taiping, Bartholomew, Blaine, Xu, Han
Publicado 2019

Author Correction: De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens

por He, Wei, Zhang, Liang, Villarreal, Oscar D., Fu, Rongjie, Bedford, Ella, Dou, Jingzhuang, Patel, Anish Y., Bedford, Mark T., Shi, Xiaobing, Chen, Taiping, Bartholomew, Blaine, Xu, Han
Publicado 2020

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

por Fu, Rongjie, He, Wei, Dou, Jinzhuang, Villarreal, Oscar D., Bedford, Ella, Wang, Helen, Hou, Connie, Zhang, Liang, Wang, Yalong, Ma, Dacheng, Chen, Yiwen, Gao, Xue, Depken, Martin, Xu, Han
Publicado 2022

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300 mutated lymphomas

por Veazey, Kylee J., Cheng, Donghang, Lin, Kevin, Villarreal, Oscar D., Gao, Guozhen, Perez-Oquendo, Mabel, Van, Hieu T., Stratton, Sabrina A., Green, Michael, Xu, Han, Lu, Yue, Bedford, Mark T., Santos, Margarida Almeida
Publicado 2020