Aging and brain rejuvenation as systemic events

por Bouchard, Jill, Villeda, Saul A
Publicado 2015

Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease

por Horowitz, Alana M., Villeda, Saul A.
Publicado 2017

Microglia communication: Parallels between aging and Alzheimer's disease

por Udeochu, Joe C., Shea, Jeremy M., Villeda, Saul A.
Publicado 2016

The systemic environment: at the interface of aging and adult neurogenesis

por Smith, Lucas K., White, Charles W., Villeda, Saul A.
Publicado 2017

Platelets Give a Running Start to Adult Hippocampal Neurogenesis

por Schroer, Adam B., Horowitz, Alana M., Villeda, Saul A.
Publicado 2019

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration

por Bieri, Gregor, Lucin, Kurt M., O’Brien, Caitlin E., Zhang, Hui, Villeda, Saul A., Wyss-Coray, Tony
Publicado 2018

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

por Gontier, Geraldine, Iyer, Manasi, Shea, Jeremy M., Bieri, Gregor, Wheatley, Elizabeth G., Ramalho-Santos, Miguel, Villeda, Saul A.
Publicado 2018

ALK5-dependent TGF-β signaling is a major determinant of late stage adult neurogenesis

por He, Yingbo, Zhang, Hui, Yung, Andrea, Villeda, Saul A, Jaeger, Philipp A, Olayiwola, Oluwatobi, Fainberg, Nina, Wyss-Coray, Tony
Publicado 2014

Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

por White, Charles W., Fan, Xuelai, Maynard, Jason C., Wheatley, Elizabeth G., Bieri, Gregor, Couthouis, Julien, Burlingame, Alma L., Villeda, Saul A.
Publicado 2020

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

por Park, Cana, Hahn, Oliver, Gupta, Shweta, Moreno, Arturo J., Marino, Francesca, Kedir, Blen, Wang, Dan, Villeda, Saul A., Wyss-Coray, Tony, Dubal, Dena B.
Publicado 2023

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain

por Wheatley, Elizabeth G., Albarran, Eddy, White, Charles W., Bieri, Gregor, Sanchez-Diaz, Cesar, Pratt, Karishma, Snethlage, Cedric E., Ding, Jun B., Villeda, Saul A.
Publicado 2019

MHC class I H2-K(b) negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling

por Lin, Karin, Bieri, Gregor, Gontier, Geraldine, Müller, Sören, Smith, Lucas K., Snethlage, Cedric E., White, Charles W., Maybury-Lewis, Sun Y., Villeda, Saul A.
Publicado 2021

Neuronal activation of G(αq) EGL-30/GNAQ late in life rejuvenates cognition across species

por Stevenson, Morgan E., Bieri, Gregor, Kaletsky, Rachel, St. Ange, Jonathan, Remesal, L., Pratt, Karishma J.B., Zhou, Shiyi, Weng, Yifei, Murphy, Coleen T., Villeda, Saul A.
Publicado 2023

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline

por Smith, Lucas K., Verovskaya, Evgenia, Bieri, Gregor, Horowitz, Alana M., von Ungern‐Sternberg, Saskia N. I., Lin, Karin, Seizer, Peter, Passegué, Emmanuelle, Villeda, Saul A.
Publicado 2020

Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

por Pratt, Karishma J.B., Shea, Jeremy M., Remesal-Gomez, Laura, Bieri, Gregor, Smith, Lucas K., Couthouis, Julien, Chen, Christopher P., Roy, Irena J., Gontier, Geraldine, Villeda, Saul A.
Publicado 2022

Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits

por Yu, Diankun, Li, Tao, Delpech, Jean-Christophe, Zhu, Beika, Kishore, Priya, Koshi, Tatsuhiro, Luo, Rong, Pratt, Karishma J.B., Popova, Galina, Nowakowski, Tomasz J., Villeda, Saul A., Piao, Xianhua
Publicado 2022

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

por Sousa-Victor, Pedro, Neves, Joana, Cedron-Craft, Wendy, Ventura, P. Britten, Liao, Chen-Yu, Riley, Rebeccah R., Soifer, Ilya, van Bruggen, Nicholas, Kolumam, Ganesh A., Villeda, Saul A., Lamba, Deepak A., Jasper, Heinrich
Publicado 2019

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

por Leiter, Odette, Brici, David, Fletcher, Stephen J., Yong, Xuan Ling Hilary, Widagdo, Jocelyn, Matigian, Nicholas, Schroer, Adam B., Bieri, Gregor, Blackmore, Daniel G., Bartlett, Perry F., Anggono, Victor, Villeda, Saul A., Walker, Tara L.
Publicado 2023

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

por Ho, Theodore T., Dellorusso, Paul V., Verovskaya, Evgenia V., Bakker, Sietske T., Flach, Johanna, Smith, Lucas K., Ventura, Patrick B., Lansinger, Olivia M., Hérault, Aurélie, Zhang, Si Yi, Kang, Yoon-A, Mitchell, Carl A., Villeda, Saul A., Passegué, Emmanuelle
Publicado 2021

Platelet factors attenuate inflammation and rescue cognition in ageing

por Schroer, Adam B., Ventura, Patrick B., Sucharov, Juliana, Misra, Rhea, Chui, M. K. Kirsten, Bieri, Gregor, Horowitz, Alana M., Smith, Lucas K., Encabo, Katriel, Tenggara, Imelda, Couthouis, Julien, Gross, Joshua D., Chan, June M., Luke, Anthony, Villeda, Saul A.
Publicado 2023