Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

por Sijbesma, Eline, Visser, Emira, Plitzko, Kathrin, Thiel, Philipp, Milroy, Lech-Gustav, Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian
Publicado 2020

Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

por Somsen, Bente A., Sijbesma, Eline, Leysen, Seppe, Honzejkova, Karolina, Visser, Emira J., Cossar, Peter J., Obšil, Tomáš, Brunsveld, Luc, Ottmann, Christian
Publicado 2023

A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers

por Kenanova, Dyana N., Visser, Emira J., Virta, Johanna M., Sijbesma, Eline, Centorrino, Federica, Vickery, Holly R., Zhong, Mengqi, Neitz, R. Jeffrey, Brunsveld, Luc, Ottmann, Christian, Arkin, Michelle R.
Publicado 2023

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

por Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.
Publicado 2023

Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues

por Somsen, Bente A., Craenmehr, Fenna W. B., Liu, Wei-Hong W., Koops, Auke A., Pennings, Marloes A. M., Visser, Emira J., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2022