Modeling and Simulation at the Interface of Nonclinical and Early Clinical Drug Development

por Visser, S A G, Manolis, E, Danhof, M, Kerbusch, T
Publicado 2013

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor

por Ortega, Fernando, Stott, Jonathan, Visser, Sandra A. G., Bendtsen, Claus
Publicado 2013

Implementation of Quantitative and Systems Pharmacology in Large Pharma

por Visser, S A G, de Alwis, D P, Kerbusch, T, Stone, J A, Allerheiligen, S R B
Publicado 2014

A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making

por Visser, Sandra A.G., Kandala, Bhargava, Fancourt, Craig, Krug, Alexander W., Cho, Carolyn R.
Publicado 2020

Building an adaptive dose simulation framework to aid dose and schedule selection

por Hooijmaijers, Richard, Parasrampuria, Ridhi, Marostica, Eleonora, Ferron‐Brady, Geraldine, Post, Teun M., Visser, Sandra A. G.
Publicado 2023

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

por Dubois, V. F. S., de Witte, W. E. A., Visser, S. A. G., Danhof, M., Della Pasqua, O.
Publicado 2015

Model‐Informed Drug Discovery and Development: Current Industry Good Practice and Regulatory Expectations and Future Perspectives

por Marshall, Scott, Madabushi, Rajanikanth, Manolis, Efthymios, Krudys, Kevin, Staab, Alexander, Dykstra, Kevin, Visser, Sandra A.G.
Publicado 2019

Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition

por Parkinson, Joanna, Ploeger, Bart, Appelkvist, Paulina, Bogstedt, Anna, Dillner Bergstedt, Karin, Eketjäll, Susanna, Visser, Sandra A G
Publicado 2013

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

por Nayak, Satyaprakash, Sander, Oliver, Al‐Huniti, Nidal, de Alwis, Dinesh, Chain, Anne, Chenel, Marylore, Sunkaraneni, Soujanya, Agrawal, Shruti, Gupta, Neeraj, Visser, Sandra A.G.
Publicado 2018

Perspective on the State of Pharmacometrics and Systems Pharmacology Integration

por Trame, Mirjam N., Riggs, Matthew, Biliouris, Konstantinos, Marathe, Dhananjay, Mettetal, Jerome, Post, Teun M., Rizk, Matthew L., Visser, Sandra A. G., Musante, Cynthia J.
Publicado 2018

Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans

por Aulin, Linda B. S., Valitalo, Pyry A., Rizk, Matthew L., Visser, Sandra A. G., Rao, Gauri, van der Graaf, Piet H., van Hasselt, J. G. Coen
Publicado 2018

MID3: Mission Impossible or Model‐Informed Drug Discovery and Development? Point‐Counterpoint Discussions on Key Challenges

por Krishnaswami, Sriram, Austin, Daren, Della Pasqua, Oscar, Gastonguay, Marc R., Gobburu, Jogarao, van der Graaf, Piet H., Ouellet, Daniele, Tannenbaum, Stacey, Visser, Sandra A. G.
Publicado 2020

Application of a systems pharmacology model for translational prediction of hERG‐mediated QTc prolongation

por Gotta, Verena, Yu, Zhiyi, Cools, Frank, van Ammel, Karel, Gallacher, David J., Visser, Sandra A. G., Sannajust, Frederick, Morissette, Pierre, Danhof, Meindert, van der Graaf, Piet H.
Publicado 2016

Model‐based meta‐analysis of non‐small cell lung cancer with standard of care PD‐1 inhibitors and chemotherapy for early development decision making

por Turner, David C., Wada, Russ, Zhou, Helen, Wang, Xiaowei, de Greef, Rik, Valiathan, Chandni, Zhang, Lindsey, Zhang, Nancy, Kuchimanchi, Mita, Chen, Tai‐Tsang, Ballas, Marc, Visser, Sandra A. G.
Publicado 2023