Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains

por Jimenez, Sebastian, Navarro, Victoria, Moyano, Javier, Sanchez-Mico, María, Torres, Manuel, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Publicado 2014

Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer’s Disease

por Romero-Molina, Carmen, Navarro, Victoria, Jimenez, Sebastian, Muñoz-Castro, Clara, Sanchez-Mico, Maria V., Gutierrez, Antonia, Vitorica, Javier, Vizuete, Marisa
Publicado 2021

Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner

por Hinojosa, María G., Prieto, Ana I., Muñoz-Castro, Clara, Sánchez-Mico, María V., Vitorica, Javier, Cameán, Ana M., Jos, Ángeles
Publicado 2022

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition...

por Pintado, Cristina, Gavilán, María P, Gavilán, Elena, García-Cuervo, Luisa, Gutiérrez, Antonia, Vitorica, Javier, Castaño, Angélica, Ríos, Rosa M, Ruano, Diego
Publicado 2012

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

por Navarro, Victoria, Sanchez-Mejias, Elisabeth, Jimenez, Sebastian, Muñoz-Castro, Clara, Sanchez-Varo, Raquel, Davila, Jose C., Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Publicado 2018

Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

por Serrano-Pozo, Alberto, Sánchez-García, Manuel A., Heras-Garvín, Antonio, March-Díaz, Rosana, Navarro, Victoria, Vizuete, Marisa, López-Barneo, José, Vitorica, Javier, Pascual, Alberto
Publicado 2017

Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease

por Salvadores, Natalia, Moreno-Gonzalez, Ines, Gamez, Nazaret, Quiroz, Gabriel, Vegas-Gomez, Laura, Escandón, Marcela, Jimenez, Sebastian, Vitorica, Javier, Gutierrez, Antonia, Soto, Claudio, Court, Felipe A.
Publicado 2022

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 h...

por Torres, Manuel, Jimenez, Sebastian, Sanchez-Varo, Raquel, Navarro, Victoria, Trujillo-Estrada, Laura, Sanchez-Mejias, Elisabeth, Carmona, Irene, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Publicado 2012

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology

por Romero-Molina, Carmen, Navarro, Victoria, Sanchez-Varo, Raquel, Jimenez, Sebastian, Fernandez-Valenzuela, Juan J., Sanchez-Mico, Maria V., Muñoz-Castro, Clara, Gutierrez, Antonia, Vitorica, Javier, Vizuete, Marisa
Publicado 2018

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

por Sanchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastian, Sanchez-Mico, Maria, Sanchez-Varo, Raquel, Nuñez-Diaz, Cristina, Trujillo-Estrada, Laura, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Publicado 2016

Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

por Garcia-Leon, Juan Antonio, Caceres-Palomo, Laura, Sanchez-Mejias, Elisabeth, Mejias-Ortega, Marina, Nuñez-Diaz, Cristina, Fernandez-Valenzuela, Juan Jose, Sanchez-Varo, Raquel, Davila, Jose Carlos, Vitorica, Javier, Gutierrez, Antonia
Publicado 2020

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology

por Trujillo-Estrada, Laura, Jimenez, Sebastian, De Castro, Vanessa, Torres, Manuel, Baglietto-Vargas, David, Moreno-Gonzalez, Ines, Navarro, Victoria, Sanchez-Varo, Raquel, Sanchez-Mejias, Elisabeth, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia, Vitorica, Javier
Publicado 2013

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease

por Baglietto-Vargas, David, Sánchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastián, Trujillo-Estrada, Laura, Gómez-Arboledas, Angela, Sánchez-Mico, Maria, Sánchez-Varo, Raquel, Vizuete, Marisa, Dávila, José Carlos, García-Verdugo, José Manuel, Vitorica, Javier, Gutierrez, Antonia
Publicado 2017

Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells

por García-Bonilla, María, Ojeda-Pérez, Betsaida, García-Martín, María L., Muñoz-Hernández, M. Carmen, Vitorica, Javier, Jiménez, Sebastián, Cifuentes, Manuel, Santos-Ruíz, Leonor, Shumilov, Kirill, Claros, Silvia, Gutiérrez, Antonia, Páez-González, Patricia, Jiménez, Antonio J.
Publicado 2020

Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

por Larramona-Arcas, Raquel, González-Arias, Candela, Perea, Gertrudis, Gutiérrez, Antonia, Vitorica, Javier, García-Barrera, Tamara, Gómez-Ariza, José Luis, Pascua-Maestro, Raquel, Ganfornina, María Dolores, Kara, Eleanna, Hudry, Eloise, Martinez-Vicente, Marta, Vila, Miquel, Galea, Elena, Masgrau, Roser
Publicado 2020

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model

por Fernandez-Valenzuela, Juan Jose, Sanchez-Varo, Raquel, Muñoz-Castro, Clara, De Castro, Vanessa, Sanchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastian, Nuñez-Diaz, Cristina, Gomez-Arboledas, Angela, Moreno-Gonzalez, Ines, Vizuete, Marisa, Davila, Jose Carlos, Vitorica, Javier, Gutierrez, Antonia
Publicado 2020

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

por Gomez‐Arboledas, Angela, Davila, Jose C., Sanchez‐Mejias, Elisabeth, Navarro, Victoria, Nuñez‐Diaz, Cristina, Sanchez‐Varo, Raquel, Sanchez‐Mico, Maria Virtudes, Trujillo‐Estrada, Laura, Fernandez‐Valenzuela, Juan Jose, Vizuete, Marisa, Comella, Joan X., Galea, Elena, Vitorica, Javier, Gutierrez, Antonia
Publicado 2017

Distinct disease‐sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients

por Sanchez‐Mejias, Elisabeth, Nuñez‐Diaz, Cristina, Sanchez‐Varo, Raquel, Gomez‐Arboledas, Angela, Garcia‐Leon, Juan Antonio, Fernandez‐Valenzuela, Juan Jose, Mejias‐Ortega, Marina, Trujillo‐Estrada, Laura, Baglietto‐Vargas, David, Moreno‐Gonzalez, Ines, Davila, Jose Carlos, Vitorica, Javier, Gutierrez, Antonia
Publicado 2019

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

por Sanchez-Varo, Raquel, Trujillo-Estrada, Laura, Sanchez-Mejias, Elisabeth, Torres, Manuel, Baglietto-Vargas, David, Moreno-Gonzalez, Ines, De Castro, Vanessa, Jimenez, Sebastian, Ruano, Diego, Vizuete, Marisa, Davila, Jose Carlos, Garcia-Verdugo, Jose Manuel, Jimenez, Antonio Jesus, Vitorica, Javier, Gutierrez, Antonia
Publicado 2011

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis

por Sanchez-Varo, Raquel, Mejias-Ortega, Marina, Fernandez-Valenzuela, Juan Jose, Nuñez-Diaz, Cristina, Caceres-Palomo, Laura, Vegas-Gomez, Laura, Sanchez-Mejias, Elisabeth, Trujillo-Estrada, Laura, Garcia-Leon, Juan Antonio, Moreno-Gonzalez, Ines, Vizuete, Marisa, Vitorica, Javier, Baglietto-Vargas, David, Gutierrez, Antonia
Publicado 2022