A Shut-and-Open Case: An Epoxide Intermediate Spotted in the Reaction Coordinate of a Family of Glycoside Hydrolases

por Vocadlo, David J.
Publicado 2020

Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases

por Pratt, Matthew R., Vocadlo, David J.
Publicado 2023

Software for rapid time dependent ChIP-sequencing analysis (TDCA)

por Myschyshyn, Mike, Farren-Dai, Marco, Chuang, Tien-Jui, Vocadlo, David
Publicado 2017

A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of O-GlcNAc Turnover on Chromatin-Associated Proteins

por Liu, Ta-Wei, Myschyshyn, Mike, Sinclair, Donald A., Vocadlo, David J.
Publicado 2019

O-GLcNAc Post-Translational Modifications Regulate the Entry of Neurons Into an Axon Branching Program

por Francisco, Herb, Kollins, Katherine, Varghis, Neal, Vocadlo, David, Vosseller, Keith, Gallo, Gianluca
Publicado 2009

Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

por Macauley, Matthew S., Shan, Xiaoyang, Yuzwa, Scott A., Gloster, Tracey M., Vocadlo, David J.
Publicado 2010

In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry

por Escobar, Edwin E., Seeley, Erin H., Serrano-Negrón, Jesús E., Vocadlo, David J., Brodbelt, Jennifer S.
Publicado 2023

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

por Macauley, Matthew S., He, Yuan, Gloster, Tracey M., Stubbs, Keith A., Davies, Gideon J., Vocadlo, David J.
Publicado 2010

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

por Gloster, Tracey M., Zandberg, Wesley F., Heinonen, Julia E., Shen, David L., Deng, Lehua, Vocadlo, David J.
Publicado 2011

Mechanism of Human Nucleocytoplasmic Hexosaminidase D

por Alteen, Matthew G., Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B. H., Vocadlo, David J., Gloster, Tracey M.
Publicado 2016

The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens

por McGuire, Bailey E., Hettle, Andrew G., Vickers, Chelsea, King, Dustin T., Vocadlo, David J., Boraston, Alisdair B.
Publicado 2021

The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity

por Meek, Richard W., Brockerman, Jacob, Fordwour, Osei B., Zandberg, Wesley F., Davies, Gideon J., Vocadlo, David J.
Publicado 2022

Human O-GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics

por Calvelo, Martín, Males, Alexandra, Alteen, Matthew G., Willems, Lianne I., Vocadlo, David J., Davies, Gideon J., Rovira, Carme
Publicado 2023

Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT

por Meek, Richard W., Blaza, James N., Busmann, Jil A., Alteen, Matthew G., Vocadlo, David J., Davies, Gideon J.
Publicado 2021

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

por Lazarus, Michael B., Jiang, Jiaoyang, Gloster, Tracey M., Zandberg, Wesley F., Whitworth, Garrett E., Vocadlo, David J., Walker, Suzanne
Publicado 2012

Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing

por Liu, Tai‐Wei, Zandberg, Wesley F., Gloster, Tracey M., Deng, Lehua, Murray, Kelsey D., Shan, Xiaoyang, Vocadlo, David J.
Publicado 2018

Immunoprecipitation and Western blot-based detection of protein O-GlcNAcylation in cells

por Ahmed, Oumaima, Affar, Malik, Masclef, Louis, Echbicheb, Mohamed, Gushul-Leclaire, Mila, Estavoyer, Benjamin, Vocadlo, David J., Affar, El Bachir
Publicado 2022

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

por Stubbs, Keith A, Bacik, John-Paul, Perley-Robertson, G Evan, Whitworth, Garrett E, Gloster, Tracey M, Vocadlo, David J, Mark, Brian L
Publicado 2013

Structural and functional insight into human O-GlcNAcase

por Roth, Christian, Chan, Sherry, Offen, Wendy A, Hemsworth, Glyn R, Willems, Lianne I, King, Dustin T, Varghese, Vimal, Britton, Robert, Vocadlo, David J, Davies, Gideon J
Publicado 2017

Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening

por Loi, Elena M., Tomašič, Tihomir, Balsollier, Cyril, van Eekelen, Kevin, Weiss, Matjaž, Gobec, Martina, Alteen, Matthew G., Vocadlo, David J., Pieters, Roland J., Anderluh, Marko
Publicado 2022