Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells

por Pérez-Rodriguez, Saumel, Wulff, Tune, Voldborg, Bjørn G., Altamirano, Claudia, Trujillo-Roldán, Mauricio A., Valdez-Cruz, Norma A.
Publicado 2021

Biochemical Characterization of Human Gluconokinase and the Proposed Metabolic Impact of Gluconic Acid as Determined by Constraint Based Metabolic Network Analysis

por Rohatgi, Neha, Nielsen, Tine Kragh, Bjørn, Sara Petersen, Axelsson, Ivar, Paglia, Giuseppe, Voldborg, Bjørn Gunnar, Palsson, Bernhard O., Rolfsson, Óttar
Publicado 2014

Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

por Dahodwala, Hussain, Kaushik, Prashant, Tejwani, Vijay, Kuo, Chih-Chung, Menard, Patrice, Henry, Michael, Voldborg, Bjorn G., Lewis, Nathan E., Meleady, Paula, Sharfstein, Susan T.
Publicado 2019

CHOmics: A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

por Lin, Dongdong, Yalamanchili, Hima B., Zhang, Xinmin, Lewis, Nathan E., Alves, Christina S., Groot, Joost, Arnsdorf, Johnny, Bjørn, Sara P., Wulff, Tune, Voldborg, Bjørn G., Zhou, Yizhou, Zhang, Baohong
Publicado 2020

Inferring secretory and metabolic pathway activity from omic data with secCellFie

por Masson, Helen O., Samoudi, Mojtaba, Robinson, Caressa M., Kuo, Chih-Chung, Weiss, Linus, Doha, Km Shams Ud, Campos, Alex, Tejwani, Vijay, Dahodwala, Hussain, Menard, Patrice, Voldborg, Bjorn G., Sharfstein, Susan T., Lewis, Nathan E.
Publicado 2023

SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression

por Gjerstorff, Morten Frier, Relster, Mette Marie, Greve, Katrine Buch Viden, Moeller, Jesper Bonnet, Elias, Daniel, Lindgreen, Jonas Nørrelund, Schmidt, Steffen, Mollenhauer, Jan, Voldborg, Bjørn, Pedersen, Christina Bøg, Brückmann, Nadine Heidi, Møllegaard, Niels Erik, Ditzel, Henrik Jørn
Publicado 2014

Combating viral contaminants in CHO cells by engineering innate immunity

por Chiang, Austin W. T., Li, Shangzhong, Kellman, Benjamin P., Chattopadhyay, Gouri, Zhang, Yaqin, Kuo, Chih-Chung, Gutierrez, Jahir M., Ghazi, Faezeh, Schmeisser, Hana, Ménard, Patrice, Bjørn, Sara Petersen, Voldborg, Bjørn G., Rosenberg, Amy S., Puig, Montserrat, Lewis, Nathan E.
Publicado 2019

Phage display assisted discovery of a pH‐dependent anti‐α‐cobratoxin antibody from a natural variable domain library

por Tulika, Tulika, Pedersen, Rasmus W., Rimbault, Charlotte, Ahmadi, Shirin, Rivera‐de‐Torre, Esperanza, Fernández‐Quintero, Monica L., Loeffler, Johannes R., Bohn, Markus‐Frederik, Ljungars, Anne, Ledsgaard, Line, Voldborg, Bjørn G., Ruso‐Julve, Fulgencio, Andersen, Jan Terje, Laustsen, Andreas H.
Publicado 2023

Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion

por van Wijk, Xander M., Döhrmann, Simon, Hallström, Björn M., Li, Shangzhong, Voldborg, Bjørn G., Meng, Brandon X., McKee, Karen K., van Kuppevelt, Toin H., Yurchenco, Peter D., Palsson, Bernhard O., Lewis, Nathan E., Nizet, Victor, Esko, Jeffrey D.
Publicado 2017

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

por Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas B., Hefzi, Hooman, Grav, Lise M., Ley, Daniel, Baycin Hizal, Deniz, Betenbaugh, Michael J., Voldborg, Bjorn, Faustrup Kildegaard, Helene, Min Lee, Gyun, Palsson, Bernhard O., Nielsen, Jens, Lewis, Nathan E.
Publicado 2020

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

por Ledsgaard, Line, Wade, Jack, Jenkins, Timothy P., Boddum, Kim, Oganesyan, Irina, Harrison, Julian A., Villar, Pedro, Leah, Rachael A., Zenobi, Renato, Schoffelen, Sanne, Voldborg, Bjørn, Ljungars, Anne, McCafferty, John, Lomonte, Bruno, Gutiérrez, José M., Laustsen, Andreas H., Karatt-Vellatt, Aneesh
Publicado 2023

Assessing developability early in the discovery process for novel biologics

por Fernández-Quintero, Monica L., Ljungars, Anne, Waibl, Franz, Greiff, Victor, Andersen, Jan Terje, Gjølberg, Torleif T., Jenkins, Timothy P., Voldborg, Bjørn Gunnar, Grav, Lise Marie, Kumar, Sandeep, Georges, Guy, Kettenberger, Hubert, Liedl, Klaus R., Tessier, Peter M., McCafferty, John, Laustsen, Andreas H.
Publicado 2023

Multiplex secretome engineering enhances recombinant protein production and purity

por Kol, Stefan, Ley, Daniel, Wulff, Tune, Decker, Marianne, Arnsdorf, Johnny, Schoffelen, Sanne, Hansen, Anders Holmgaard, Jensen, Tanja Lyholm, Gutierrez, Jahir M., Chiang, Austin W. T., Masson, Helen O., Palsson, Bernhard O., Voldborg, Bjørn G., Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
Publicado 2020