Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

por Kumar, Prashant, Bird, Christopher, Holland, David, Joshi, Sangeeta B., Volkin, David B.
Publicado 2022

The Science is There: Key Considerations for Stabilizing Viral Vector-Based Covid-19 Vaccines

por Crommelin, Daan J.A., Volkin, David B., Hoogendoorn, Karin H., Lubiniecki, Anthony S., Jiskoot, Wim
Publicado 2021

Addressing the Cold Reality of mRNA Vaccine Stability

por Crommelin, Daan J.A., Anchordoquy, Thomas J., Volkin, David B., Jiskoot, Wim, Mastrobattista, Enrico
Publicado 2021

Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles

por Alsenaidy, Mohammad A., Jain, Nishant K., Kim, Jae H., Middaugh, C. Russell, Volkin, David B.
Publicado 2014

Crystallization of a nonreplicating rotavirus vaccine candidate

por Hong, Moo Sun, Kaur, Kawaljit, Sawant, Nishant, Joshi, Sangeeta B., Volkin, David B., Braatz, Richard D.
Publicado 2021

Comparison of Protein Particle Formation in IgG1 mAbs Formulated with PS20 Vs. PS80 When Subjected to Interfacial Dilatational Stress

por Vaclaw, Coleman, Merritt, Kimberly, Griffin, Valerie P., Whitaker, Neal, Gokhale, Madhushree, Volkin, David B., Ogunyankin, Maria O., Dhar, Prajnaparamita
Publicado 2023

Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch™ Microprojection Array

por Wan, Ying, Hickey, John M., Bird, Christopher, Witham, Katey, Fahey, Paul, Forster, Angus, Joshi, Sangeeta B., Volkin, David B.
Publicado 2018

Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral Vaccine Dried for Use in the Nanopatch(TM) Microneedle Delivery System

por Wan, Ying, Gupta, Vineet, Bird, Christopher, Pullagurla, Swathi R., Fahey, Paul, Forster, Angus, Volkin, David B., Joshi, Sangeeta B.
Publicado 2021

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

por Toprani, Vishal M., Sahni, Neha, Hickey, John M., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publicado 2017

Characterizing and Minimizing Aggregation and Particle Formation of Three Recombinant Fusion-Protein Bulk Antigens for Use in a Candidate Trivalent Rotavirus Vaccine

por Agarwal, Sanjeev, Sahni, Neha, Hickey, John M., Robertson, George A., Sitrin, Robert, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Publicado 2020

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

por Lee, Shwu-Maan, Hickey, John M., Miura, Kazutoyo, Joshi, Sangeeta B., Volkin, David B., King, C. Richter, Plieskatt, Jordan L.
Publicado 2020

Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice...

por Xiao, Yuhong, Zeng, Yuhong, Schante, Carole, Joshi, Sangeeta B., Buchman, George W., Volkin, David B., Middaugh, C. Russell, Isaacs, Stuart N.
Publicado 2020

The Storage and In-Use Stability of mRNA Vaccines and Therapeutics: Not A Cold Case

por Oude Blenke, Erik, Örnskov, Eivor, Schöneich, Christian, Nilsson, Gunilla A., Volkin, David B., Mastrobattista, Enrico, Almarsson, Örn, Crommelin, Daan J.A.
Publicado 2023

Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

por Kumar, Prashant, Wang, Michael, Kumru, Ozan S., Hickey, John M., Sanmiguel, Julio, Zabaleta, Nerea, Vandenberghe, Luk H., Joshi, Sangeeta B., Volkin, David B.
Publicado 2023

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant

por Toprani, Vishal M., Hickey, John M., Sahni, Neha, Toth, Ronald T., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publicado 2017

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

por Arora, Jayant, Hickey, John M, Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Weis, David D, Volkin, David B
Publicado 2015

Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies

por Patel, Ashaben, Gupta, Vineet, Hickey, John, Nightlinger, Nancy S., Rogers, Richard S., Siska, Christine, Joshi, Sangeeta B., Seaman, Michael S., Volkin, David B., Kerwin, Bruce A.
Publicado 2018

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

por Lee, Shwu-Maan, Wu, Yimin, Hickey, John M., Miura, Kazutoyo, Whitaker, Neal, Joshi, Sangeeta B., Volkin, David B., Richter King, C., Plieskatt, Jordan
Publicado 2019

Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration

por Hu, Yue, Kumru, Ozan S., Xiong, Jian, Antunez, Lorena R., Hickey, John, Wang, Yang, Cavacini, Lisa, Klempner, Mark, Joshi, Sangeeta B., Volkin, David B.
Publicado 2020

Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens

por Agarwal, Sanjeev, Hickey, John M., McAdams, David, White, Jessica A., Sitrin, Robert, Khandke, Lakshmi, Cryz, Stanley, Joshi, Sangeeta B., Volkin, David B.
Publicado 2020