Lysosomal Pathogenesis of Parkinson’s Disease: Insights From LRRK2 and GBA1 Rodent Models

por Volta, Mattia
Publicado 2022

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease

por Lamonaca, Giulia, Volta, Mattia
Publicado 2020

LRRK2 along the Golgi and lysosome connection: a jamming situation

por Piccoli, Giovanni, Volta, Mattia
Publicado 2021

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration

por Volta, Mattia, Lewis, Patrick A., Lobbestael, Evy
Publicado 2020

A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics

por Obergasteiger, Julia, Frapporti, Giulia, Pramstaller, Peter P., Hicks, Andrew A., Volta, Mattia
Publicado 2018

Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out

por MacIsaac, Sarah, Quevedo Melo, Thaiany, Zhang, Yuting, Volta, Mattia, Farrer, Matthew J, Milnerwood, Austen J
Publicado 2020

Cryopreservation of Primary Mouse Neurons: The Benefit of Neurostore Cryoprotective Medium

por Pischedda, Francesca, Montani, Caterina, Obergasteiger, Julia, Frapporti, Giulia, Corti, Corrado, Rosato Siri, Marcelo, Volta, Mattia, Piccoli, Giovanni
Publicado 2018

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

por Beccano-Kelly, Dayne A., Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N., Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J., Milnerwood, Austen J.
Publicado 2014

The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology

por Obergasteiger, Julia, Castonguay, Anne-Marie, Pizzi, Sara, Magnabosco, Stefano, Frapporti, Giulia, Lobbestael, Evy, Baekelandt, Veerle, Hicks, Andrew A., Pramstaller, Peter P., Gravel, Claude, Corti, Corrado, Lévesque, Martin, Volta, Mattia
Publicado 2023

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

por Obergasteiger, Julia, Frapporti, Giulia, Lamonaca, Giulia, Pizzi, Sara, Picard, Anne, Lavdas, Alexandros A., Pischedda, Francesca, Piccoli, Giovanni, Hilfiker, Sabine, Lobbestael, Evy, Baekelandt, Veerle, Hicks, Andrew A., Corti, Corrado, Pramstaller, Peter P., Volta, Mattia
Publicado 2020

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

por Volta, Mattia, Beccano-Kelly, Dayne A, Paschall, Sarah A, Cataldi, Stefano, MacIsaac, Sarah E, Kuhlmann, Naila, Kadgien, Chelsie A, Tatarnikov, Igor, Fox, Jesse, Khinda, Jaskaran, Mitchell, Emma, Bergeron, Sabrina, Melrose, Heather, Farrer, Matthew J, Milnerwood, Austen J
Publicado 2017

Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

por Überbacher, Christa, Obergasteiger, Julia, Volta, Mattia, Venezia, Serena, Müller, Stefan, Pesce, Isabella, Pizzi, Sara, Lamonaca, Giulia, Picard, Anne, Cattelan, Giada, Malpeli, Giorgio, Zoli, Michele, Beccano-Kelly, Dayne, Flynn, Rowan, Wade-Martins, Richard, Pramstaller, Peter P., Hicks, Andrew A., Cowley, Sally A., Corti, Corrado
Publicado 2019