Radionuclides in Diagnostics and Therapy of Malignant Tumors: New Development

por Tolmachev, Vladimir, Vorobyeva, Anzhelika
Publicado 2022

Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules

por Garousi, Javad, Vorobyeva, Anzhelika, Altai, Mohamed
Publicado 2020

On the prevention of kidney uptake of radiolabeled DARPins

por Altai, Mohamed, Garousi, Javad, Rinne, Sara S., Schulga, Alexey, Deyev, Sergey, Vorobyeva, Anzhelika
Publicado 2020

Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with (99m)Tc and (125)I

por Tolmachev, Vladimir, Bodenko, Vitalina, Orlova, Anna, Schulga, Alexey, Deyev, Sergey M., Vorobyeva, Anzhelika
Publicado 2022

Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

por Vorobyeva, Anzhelika, Schulga, Alexey, Rinne, Sara S., Günther, Tyran, Orlova, Anna, Deyev, Sergey, Tolmachev, Vladimir
Publicado 2019

Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody–DM1 Drug Conjugates

por Ding, Haozhong, Altai, Mohamed, Rinne, Sara S., Vorobyeva, Anzhelika, Tolmachev, Vladimir, Gräslund, Torbjörn, Orlova, Anna
Publicado 2019

Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

por Xu, Tianqi, Ding, Haozhong, Vorobyeva, Anzhelika, Oroujeni, Maryam, Orlova, Anna, Tolmachev, Vladimir, Gräslund, Torbjörn
Publicado 2020

Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells

por Xu, Tianqi, Liu, Yongsheng, Schulga, Alexey, Konovalova, Elena, Deyev, Sergey M., Tolmachev, Vladimir, Vorobyeva, Anzhelika
Publicado 2022

Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m

por Garousi, Javad, Lindbo, Sarah, Mitran, Bogdan, Buijs, Jos, Vorobyeva, Anzhelika, Orlova, Anna, Tolmachev, Vladimir, Hober, Sophia
Publicado 2017

Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein

por Vorobyeva, Anzhelika, Oroujeni, Maryam, Lindbo, Sarah, Hober, Sophia, Xu, Tianqi, Liu, Yongsheng, Rinne, Sara S., Garousi, Javad
Publicado 2020

Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

por Ding, Haozhong, Xu, Tianqi, Zhang, Jie, Tolmachev, Vladimir, Oroujeni, Maryam, Orlova, Anna, Gräslund, Torbjörn, Vorobyeva, Anzhelika
Publicado 2021

Radionuclide Therapy of HER2-Expressing Xenografts Using [(177)Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

por Liu, Yongsheng, Xu, Tianqi, Vorobyeva, Anzhelika, Loftenius, Annika, Bodenko, Vitalina, Orlova, Anna, Frejd, Fredrik Y., Tolmachev, Vladimir
Publicado 2023

Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

por Rinne, Sara S., Xu, Tianqi, Dahlsson Leitao, Charles, Ståhl, Stefan, Löfblom, John, Orlova, Anna, Tolmachev, Vladimir, Vorobyeva, Anzhelika
Publicado 2020

HER3 PET Imaging: (68)Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to (89)Zr-Labeled Antibody and Antibody-Fragment-Based Tracers

por Rinne, Sara S., Leitao, Charles Dahlsson, Abouzayed, Ayman, Vorobyeva, Anzhelika, Tolmachev, Vladimir, Ståhl, Stefan, Löfblom, John, Orlova, Anna
Publicado 2021

Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

por Garousi, Javad, Xu, Tianqi, Liu, Yongsheng, Vorontsova, Olga, Hober, Sophia, Orlova, Anna, Tolmachev, Vladimir, Gräslund, Torbjörn, Vorobyeva, Anzhelika
Publicado 2022

Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy

por Vorobyeva, Anzhelika, Westerlund, Kristina, Mitran, Bogdan, Altai, Mohamed, Rinne, Sara, Sörensen, Jens, Orlova, Anna, Tolmachev, Vladimir, Karlström, Amelie Eriksson
Publicado 2018

Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

por Altai, Mohamed, Leitao, Charles Dahlsson, Rinne, Sara S., Vorobyeva, Anzhelika, Atterby, Christina, Ståhl, Stefan, Tolmachev, Vladimir, Löfblom, John, Orlova, Anna
Publicado 2018

Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting

por Myrhammar, Anders, Vorobyeva, Anzhelika, Westerlund, Kristina, Yoneoka, Shuichiro, Orlova, Anna, Tsukahara, Takehiko, Tolmachev, Vladimir, Karlström, Amelie Eriksson, Altai, Mohamed
Publicado 2020

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody(®) Molecules (177)Lu-ABY-271 and (177)Lu-ABY-027: Impact of DOTA Position on ABD Domain

por Liu, Yongsheng, Vorobyeva, Anzhelika, Xu, Tianqi, Orlova, Anna, Loftenius, Annika, Bengtsson, Theresa, Jonasson, Per, Tolmachev, Vladimir, Frejd, Fredrik Y.
Publicado 2021

Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors

por Vorobyeva, Anzhelika, Bragina, Olga, Altai, Mohamed, Mitran, Bogdan, Orlova, Anna, Shulga, Alexey, Proshkina, Galina, Chernov, Vladimir, Tolmachev, Vladimir, Deyev, Sergey
Publicado 2018