Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

por Syvänen, Stina, Schenke, Maarten, van den Berg, Dirk-Jan, Voskuyl, Rob A., de Lange, Elizabeth C.
Publicado 2012

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[(11)C]verapamil positron emission tomography

por Müllauer, Julia, Kuntner, Claudia, Bauer, Martin, Bankstahl, Jens P, Müller, Markus, Voskuyl, Rob A, Langer, Oliver, Syvänen, Stina
Publicado 2012

(R)-[(11)C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

por Syvänen, Stina, Luurtsema, Gert, Molthoff, Carla FM, Windhorst, Albert D, Huisman, Marc C, Lammertsma, Adriaan A, Voskuyl, Rob A, de Lange, Elizabeth C
Publicado 2011

[(11)C]phenytoin revisited: synthesis by [(11)C]CO carbonylation and first evaluation as a P-gp tracer in rats

por Verbeek, Joost, Eriksson, Jonas, Syvänen, Stina, Labots, Maaike, de Lange, Elizabeth C M, Voskuyl, Rob A, Mooijer, Martinus P J, Rongen, Marissa, Lammertsma, Adriaan A, Windhorst, Albert D
Publicado 2012

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells

por Schouten, Marijn, Fratantoni, Silvina A., Hubens, Chantal J., Piersma, Sander R., Pham, Thang V., Bielefeld, Pascal, Voskuyl, Rob A., Lucassen, Paul J., Jimenez, Connie R., Fitzsimons, Carlos P.
Publicado 2015

Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus

por Schouten, Marijn, Bielefeld, Pascal, Fratantoni, Silvina A., Hubens, Chantal J., Piersma, Sander R., Pham, Thang V., Voskuyl, Rob A., Lucassen, Paul J., Jimenez, Connie R., Fitzsimons, Carlos P.
Publicado 2016

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([(18)F]4FIMPTC) as a novel PET tracer of P-glycoprotein exp...

por Verbeek, Joost, Eriksson, Jonas, Syvänen, Stina, Huisman, Marc, Schuit, Robert C., Molthoff, Carla F. M., Voskuyl, Rob A., de Lange, Elizabeth C., Lammertsma, Adriaan A., Windhorst, Albert D.
Publicado 2018

[(11)C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

por Froklage, Femke E, Syvänen, Stina, Hendrikse, N Harry, Huisman, Marc C, Molthoff, Carla FM, Tagawa, Yoshihiko, Reijneveld, Jaap C, Heimans, Jan J, Lammertsma, Adriaan A, Eriksson, Jonas, de Lange, Elizabeth CM, Voskuyl, Rob A
Publicado 2012

Altered GABA(A) receptor density and unaltered blood–brain barrier [(11)C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis

por Froklage, Femke E, Postnov, Andrey, Yaqub, Maqsood M, Bakker, Esther, Boellaard, Ronald, Hendrikse, N Harry, Comans, Emile FI, Schuit, Robert C, Schober, Patrick, Velis, Demetrios N, Zwemmer, Jack, Heimans, Jan J, Lammertsma, Adriaan A, Voskuyl, Rob A, Reijneveld, Jaap C
Publicado 2015