Chemical Methods to Induce Beta-Cell Proliferation

por Vetere, Amedeo, Wagner, Bridget K.
Publicado 2012

Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides

por Scully, Stephen S., Zheng, Shao-Liang, Wagner, Bridget K., Schreiber, Stuart L.
Publicado 2015

GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity

por Fomina-Yadlin, Dina, Kubicek, Stefan, Vetere, Amedeo, He, Kaihui Hu, Schreiber, Stuart L., Wagner, Bridget K.
Publicado 2012

Correction: GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity

por Fomina-Yadlin, Dina, Kubicek, Stefan, Vetere, Amedeo, Hu He, Kai Hui, Schreiber, Stuart L., Wagner, Bridget K.
Publicado 2012

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

por Lim, Donghyun, Sreekanth, Vedagopuram, Cox, Kurt J., Law, Benjamin K., Wagner, Bridget K., Karp, Jeffrey M., Choudhary, Amit
Publicado 2020

Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells

por Kahraman, Sevim, Manna, Debasish, Dirice, Ercument, Maji, Basudeb, Small, Jonnell, Wagner, Bridget K, Choudhary, Amit, Kulkarni, Rohit N
Publicado 2021

Assay of the Multiple Energy-Producing Pathways of Mammalian Cells

por Bochner, Barry R., Siri, Mark, Huang, Richard H., Noble, Shawn, Lei, Xiang-He, Clemons, Paul A., Wagner, Bridget K.
Publicado 2011

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

por Maianti, Juan Pablo, Tan, Grace A., Vetere, Amedeo, Welsh, Amie J., Wagner, Bridget K., Seeliger, Markus A., Liu, David R.
Publicado 2019

Large-scale chemical dissection of mitochondrial function

por Wagner, Bridget K., Kitami, Toshimori, Gilbert, Tamara J., Peck, David, Ramanathan, Arvind, Schreiber, Stuart L., Golub, Todd R., Mootha, Vamsi K.
Publicado 2008

A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma

por Yuan, Yuan, Wang, Qiu, Paulk, Joshiawa, Kubicek, Stefan, Kemp, Melissa M., Adams, Drew J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L.
Publicado 2012

Predicting compound activity from phenotypic profiles and chemical structures

por Moshkov, Nikita, Becker, Tim, Yang, Kevin, Horvath, Peter, Dancik, Vlado, Wagner, Bridget K., Clemons, Paul A., Singh, Shantanu, Carpenter, Anne E., Caicedo, Juan C.
Publicado 2023

Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death

por Adams, Drew J., Boskovic, Zarko V., Theriault, Jimmy R., Wang, Alex J., Stern, Andrew M., Wagner, Bridget K., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado 2013

From type 1 diabetes biology to therapy: The Human Islet Research Network

por Kaddis, John S., Rouse, Layla, Parent, Audrey V., Saunders, Diane C., Shalev, Anath, Stabler, Cherie L., Stoffers, Doris A., Wagner, Bridget K., Niland, Joyce C.
Publicado 2021

Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells

por Dahlby, Tina, Simon, Christian, Backe, Marie Balslev, Dahllöf, Mattias Salling, Holson, Edward, Wagner, Bridget K., Böni-Schnetzler, Marianne, Marzec, Michal Tomasz, Lundh, Morten, Mandrup-Poulsen, Thomas
Publicado 2020

Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity

por Small, Jonnell C., Joblin-Mills, Aidan, Carbone, Kaycee, Kost-Alimova, Maria, Ayukawa, Kumiko, Khodier, Carol, Dancik, Vlado, Clemons, Paul A., Munkacsi, Andrew B., Wagner, Bridget K.
Publicado 2022

Quantitative-Proteomic Comparison of Alpha and Beta Cells to Uncover Novel Targets for Lineage Reprogramming

por Choudhary, Amit, Hu He, Kaihui, Mertins, Philipp, Udeshi, Namrata D., Dančík, Vlado, Fomina-Yadlin, Dina, Kubicek, Stefan, Clemons, Paul A., Schreiber, Stuart L., Carr, Steven A., Wagner, Bridget K.
Publicado 2014

Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells

por Lee, Miseon, Maji, Basudeb, Manna, Debasish, Kahraman, Sevim, Elgamal, Ruth M., Small, Jonnell, Kokkonda, Praveen, Vetere, Amedeo, Goldberg, Jacob M., Lippard, Stephen J., Kulkarni, Rohit N., Wagner, Bridget K., Choudhary, Amit
Publicado 2020

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

por Dirice, Ercument, Walpita, Deepika, Vetere, Amedeo, Meier, Bennett C., Kahraman, Sevim, Hu, Jiang, Dančík, Vlado, Burns, Sean M., Gilbert, Tamara J., Olson, David E., Clemons, Paul A., Kulkarni, Rohit N., Wagner, Bridget K.
Publicado 2016

Real-Time Biological Annotation of Synthetic Compounds

por Gerry, Christopher J., Hua, Bruce K., Wawer, Mathias J., Knowles, Jonathan P., Nelson Jr., Shawn D., Verho, Oscar, Dandapani, Sivaraman, Wagner, Bridget K., Clemons, Paul A., Booker-Milburn, Kevin I., Boskovic, Zarko V., Schreiber, Stuart L.
Publicado 2016

A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells

por Yang, Kisuk, Lee, Miseon, Jones, Peter Anthony, Liu, Sophie S., Zhou, Angela, Xu, Jun, Sreekanth, Vedagopuram, Wu, Jamie L. Y., Vo, Lillian, Lee, Eunjee A., Pop, Ramona, Lee, Yuhan, Wagner, Bridget K., Melton, Douglas A., Choudhary, Amit, Karp, Jeffrey M.
Publicado 2020