Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway

por Das, Utpal, Wang, Lina, Ganguly, Archan, Saikia, Junmi M., Wagner, Steven L., Koo, Edward H., Roy, Subhojit
Publicado 2015

NOVEL GAMMA-SECRETASE MODULATOR REGULATES APP PROCESSING AND INFLAMMATORY RESPONSES IN NPM-EXPOSED MICE

por D'Agostino, Carla, Cacciottolo, Mafalda, Sioutas, Constantinos, Wagner, Steven L, Tanzi, Rudolph E, Morgan, Todd E, Finch, Caleb E
Publicado 2019

Dedifferentiation and neuronal repression define familial Alzheimer’s disease

por Caldwell, Andrew B., Liu, Qing, Schroth, Gary P., Galasko, Douglas R., Yuan, Shauna H., Wagner, Steven L., Subramaniam, Shankar
Publicado 2020

Transcriptomic profiling of sporadic Alzheimer’s disease patients

por Caldwell, Andrew B., Anantharaman, Balaji G., Ramachandran, Srinivasan, Nguyen, Phuong, Liu, Qing, Trinh, Ivy, Galasko, Douglas R., Desplats, Paula A., Wagner, Steven L., Subramaniam, Shankar
Publicado 2022

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β...

por Wagner, Steven L., Zhang, Can, Cheng, Soan, Nguyen, Phuong, Zhang, Xulun, Rynearson, Kevin D., Wang, Rong, Li, Yueming, Sisodia, Sangram S., Mobley, William C., Tanzi, Rudolph E.
Publicado 2014

Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease

por Caldwell, Andrew B., Liu, Qing, Zhang, Can, Schroth, Gary P., Galasko, Douglas R., Rynearson, Kevin D., Tanzi, Rudolph E., Yuan, Shauna H., Wagner, Steven L., Subramaniam, Shankar
Publicado 2022

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease

por Perrin, Florian, Anderson, Lauren C., Mitchell, Shane P.C., Sinha, Priyanka, Turchyna, Yuliia, Maesako, Masato, Houser, Mei C.Q., Zhang, Can, Wagner, Steven L., Tanzi, Rudolph E., Berezovska, Oksana
Publicado 2023

STIM1, an essential and conserved component of store-operated Ca(2+) channel function

por Roos, Jack, DiGregorio, Paul J., Yeromin, Andriy V., Ohlsen, Kari, Lioudyno, Maria, Zhang, Shenyuan, Safrina, Olga, Kozak, J. Ashot, Wagner, Steven L., Cahalan, Michael D., Veliçelebi, Gönül, Stauderman, Kenneth A.
Publicado 2005

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP

por Weissmiller, April M., Natera-Naranjo, Orlangie, Reyna, Sol M., Pearn, Matthew L., Zhao, Xiaobei, Nguyen, Phuong, Cheng, Soan, Goldstein, Lawrence S. B., Tanzi, Rudolph E., Wagner, Steven L., Mobley, William C., Wu, Chengbiao
Publicado 2015

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

por Raven, Frank, Ward, Joseph F., Zoltowska, Katarzyna M., Wan, Yu, Bylykbashi, Enjana, Miller, Sean J., Shen, Xunuo, Choi, Se Hoon, Rynearson, Kevin D., Berezovska, Oksana, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
Publicado 2017

Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates

por Xu, Yulong, Wang, Changning, Wey, Hsiao-Ying, Liang, Yingxia, Chen, Zude, Choi, Se Hoon, Ran, Chongzhao, Rynearson, Kevin D., Bernales, Daniela R., Koegel, Robert E., Fiedler, Stephanie A., Striar, Robin, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
Publicado 2020

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

por Kwak, Sang Su, Washicosky, Kevin J., Brand, Emma, von Maydell, Djuna, Aronson, Jenna, Kim, Susan, Capen, Diane E., Cetinbas, Murat, Sadreyev, Ruslan, Ning, Shen, Bylykbashi, Enjana, Xia, Weiming, Wagner, Steven L., Choi, Se Hoon, Tanzi, Rudolph E., Kim, Doo Yeon
Publicado 2020

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

por van der Kant, Rik, Langness, Vanessa F., Herrera, Cheryl M., Williams, Daniel A., Fong, Lauren K., Leestemaker, Yves, Steenvoorden, Evelyne, Rynearson, Kevin D., Brouwers, Jos F., Helms, J. Bernd, Ovaa, Huib, Giera, Martin, Wagner, Steven L., Bang, Anne G., Goldstein, Lawrence S.B.
Publicado 2019

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

por Wagner, Steven L., Rynearson, Kevin D., Duddy, Steven K., Zhang, Can, Nguyen, Phuong D., Becker, Ann, Vo, Uyen, Masliah, Deborah, Monte, Louise, Klee, Justin B., Echmalian, Corinne M., Xia, Weiming, Quinti, Luisa, Johnson, Graham, Lin, Jiunn H., Kim, Doo Y., Mobley, William C., Rissman, Robert A., Tanzi, Rudolph E.
Publicado 2017

Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention

por Rynearson, Kevin D., Ponnusamy, Moorthi, Prikhodko, Olga, Xie, Yuhuan, Zhang, Can, Nguyen, Phuong, Hug, Brenda, Sawa, Mariko, Becker, Ann, Spencer, Brian, Florio, Jazmin, Mante, Michael, Salehi, Bahar, Arias, Carlos, Galasko, Douglas, Head, Brian P., Johnson, Graham, Lin, Jiunn H., Duddy, Steven K., Rissman, Robert A., Mobley, William C., Thinakaran, Gopal, Tanzi, Rudolph E., Wagner, Steven L.
Publicado 2021