Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia

por Walker, Callum, El-Khamisy, Sherif F
Publicado 2018

Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation

por Muto, Tomoya, Walker, Callum S., Agarwal, Puneet, Vick, Eric, Sampson, Avery, Choi, Kwangmin, Niederkorn, Madeline, Ishikawa, Chiharu, Hueneman, Kathleen, Varney, Melinda, Starczynowski, Daniel T.
Publicado 2023

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

por Bajrami, Ilirjana, Walker, Callum, Krastev, Dragomir B., Weekes, Daniel, Song, Feifei, Wicks, Andrew J., Alexander, John, Haider, Syed, Brough, Rachel, Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.
Publicado 2021

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

por Tarantino, Dalia, Walker, Callum, Weekes, Daniel, Pemberton, Helen, Davidson, Kathryn, Torga, Gonzalo, Frankum, Jessica, Mendes-Pereira, Ana M., Prince, Cynthia, Ferro, Riccardo, Brough, Rachel, Pettitt, Stephen J., Lord, Christopher J., Grigoriadis, Anita, NJ Tutt, Andrew
Publicado 2022

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

por Fang, Jing, Muto, Tomoya, Kleppe, Maria, Bolanos, Lyndsey C., Hueneman, Kathleen M., Walker, Callum S., Sampson, Leesa, Wellendorf, Ashley M., Chetal, Kashish, Choi, Kwangmin, Salomonis, Nathan, Choi, Yongwon, Zheng, Yi, Cancelas, Jose A., Levine, Ross L., Starczynowski, Daniel T.
Publicado 2018

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

por Herranz-Martin, Saul, Chandran, Jayanth, Lewis, Katherine, Mulcahy, Padraig, Higginbottom, Adrian, Walker, Callum, Valenzuela, Isabel Martinez-Pena y, Jones, Ross A., Coldicott, Ian, Iannitti, Tommaso, Akaaboune, Mohammed, El-Khamisy, Sherif F., Gillingwater, Thomas H., Shaw, Pamela J., Azzouz, Mimoun
Publicado 2017

C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair

por Walker, Callum, Herranz-Martin, Saul, Karyka, Evangelia, Liao, Chunyan, Lewis, Katherine, Elsayed, Waheba, Lukashchuk, Vera, Chiang, Shih-Chieh, Ray, Swagat, Mulcahy, Padraig J., Jurga, Mateusz, Tsagakis, Ioannis, Iannitti, Tommaso, Chandran, Jayanth, Coldicott, Ian, De Vos, Kurt J., Hassan, Mohamed K., Higginbottom, Adrian, Shaw, Pamela J., Hautbergue, Guillaume M., Azzouz, Mimoun, El-Khamisy, Sherif F.
Publicado 2017