Impacting T-cell fitness in multiple myeloma: potential roles for selinexor and XPO1 inhibitors

por Binder, Adam F., Walker, Christopher J., Mark, Tomer M., Baljevic, Muhamed
Publicado 2023

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

por Walker, Christopher J., Chang, Hua, Henegar, Leah, Kashyap, Trinayan, Shacham, Sharon, Sommer, Josh, Wick, Michael J., Levy, Joan, Landesman, Yosef
Publicado 2022

Next-Generation SINE Compound KPT−8602 Ameliorates Dystrophic Pathology in Zebrafish and Mouse Models of DMD

por English, Katherine G., Reid, Andrea L., Samani, Adrienne, Coulis, Gerald J. F., Villalta, S. Armando, Walker, Christopher J., Tamir, Sharon, Alexander, Matthew S.
Publicado 2022

Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects

por Li, Shirong, Fu, Jing, Walker, Christopher J., Yang, Jun, Bhutani, Divaya, Chakraborty, Rajshekhar, Mamillapalli, Niha, Mapara, Markus Y., Landesman, Yosef, Lentzsch, Suzanne
Publicado 2023

Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

por Kashyap, Trinayan, Murray, Jackelyn, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Hou, Bing, Shacham, Sharon, Kauffman, Michael G., Tripp, Ralph A., Landesman, Yosef
Publicado 2021

Selinexor Enhances NK Cell Activation Against Malignant B Cells via Downregulation of HLA-E

por Fisher, Jack G., Walker, Christopher J., Doyle, Amber DP., Johnson, Peter WM., Forconi, Francesco, Cragg, Mark S., Landesman, Yosef, Khakoo, Salim. I., Blunt, Matthew D.
Publicado 2021

Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma

por Mittal, Sonam, Kadamberi, Ishaque Pulikkal, Chang, Hua, Wang, Feng, Kumar, Sudhir, Tsaih, Shirng-Wern, Walker, Christopher J., Chaluvally-Raghavan, Pradeep, Charlson, John, Landesman, Yosef, Pradeep, Sunila
Publicado 2023

Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations

por Walker, Christopher J., O'Hern, Matthew J., Serna, Vanida A., Kurita, Takeshi, Miranda, Mario A., Sapp, Caroline E., Mutch, David G., Cohn, David E., Goodfellow, Paul J.
Publicado 2017

XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression

por Fisher, Jack G., Doyle, Amber D. P., Graham, Lara V., Sonar, Shreyanshi, Sale, Ben, Henderson, Isla, Del Rio, Luis, Johnson, Peter W. M., Landesman, Yosef, Cragg, Mark S., Forconi, Francesco, Walker, Christopher J., Khakoo, Salim. I., Blunt, Matthew D.
Publicado 2023

No evidence for microsatellite instability in acute myeloid leukemia

por Walker, Christopher J., Eisfeld, Ann-Kathrin, Genutis, Luke K., Bainazar, Maryam, Kohlschmidt, Jessica, Mrózek, Krzysztof, Carroll, Andrew J., Kolitz, Jonathan E., Powell, Bayard L., Wang, Eunice S., Stone, Richard M., Bundschuh, Ralf, de la Chapelle, Albert, Bloomfield, Clara D.
Publicado 2017

Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: an analysis of Alliance studies

por Eisfeld, Ann-Kathrin, Kohlschmidt, Jessica, Mrózek, Krzysztof, Blachly, James S., Walker, Christopher J., Nicolet, Deedra, Orwick, Shelley, Maharry, Sophia E., Carroll, Andrew J., Stone, Richard M., de la Chapelle, Albert, Wang, Eunice S., Kolitz, Jonathan E., Powell, Bayard L., Byrd, John C., Bloomfield, Clara D.
Publicado 2018

Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically

por Mrózek, Krzysztof, Eisfeld, Ann-Kathrin, Kohlschmidt, Jessica, Carroll, Andrew J., Walker, Christopher J., Nicolet, Deedra, Blachly, James S., Bill, Marius, Papaioannou, Dimitrios, Wang, Eunice S., Uy, Geoffrey L., Kolitz, Jonathan E., Powell, Bayard L., Blum, William, Stone, Richard M., Byrd, John C., Bloomfield, Clara D.
Publicado 2019

NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome

por Eisfeld, Ann-Kathrin, Kohlschmidt, Jessica, Mrózek, Krzysztof, Mims, Alice, Walker, Christopher J., Blachly, James S., Nicolet, Deedra, Orwick, Shelley, Maharry, Sophia E., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Wang, Eunice S., Stone, Richard M., de la Chapelle, Albert, Byrd, John C., Bloomfield, Clara D.
Publicado 2018

Mutations associated with a 17-gene leukemia stem cell score and the score’s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemi...

por Bill, Marius, Nicolet, Deedra, Kohlschmidt, Jessica, Walker, Christopher J., Mrózek, Krzysztof, Eisfeld, Ann-Kathrin, Papaioannou, Dimitrios, Rong-Mullins, Xiaoqing, Brannan, Zachary, Kolitz, Jonathan E., Powell, Bayard L., Archer, Kellie J., Dorrance, Adrienne M., Carroll, Andrew J., Stone, Richard M., Byrd, John C., Garzon, Ramiro, Bloomfield, Clara D.
Publicado 2020

A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma

por Lassman, Andrew B., Wen, Patrick Y., van den Bent, Martin J., Plotkin, Scott R., Walenkamp, Annemiek M.E., Green, Adam L., Li, Kai, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Henegar, Leah, Shen, Yao, Alvarez, Mariano J., Califano, Andrea, Landesman, Yosef, Kauffman, Michael G., Shacham, Sharon, Mau-Sørensen, Morten
Publicado 2022

Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA

por Walker, Christopher J., Oakes, Christopher C., Genutis, Luke K., Giacopelli, Brian, Liyanarachchi, Sandya, Nicolet, Deedra, Eisfeld, Ann-Kathrin, Scholz, Markus, Brock, Pamela, Kohlschmidt, Jessica, Mrózek, Krzysztof, Bill, Marius, Carroll, Andrew J., Kolitz, Jonathan E., Powell, Bayard L., Wang, Eunice S., Niederwieser, Dietger W., Stone, Richard M., Byrd, John C., Schwind, Sebastian, de la Chapelle, Albert, Bloomfield, Clara D.
Publicado 2018

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia

por Papaioannou, Dimitrios, Ozer, Hatice G., Nicolet, Deedra, Urs, Amog P., Herold, Tobias, Mrózek, Krzysztof, Batcha, Aarif M.N., Metzeler, Klaus H., Yilmaz, Ayse S., Volinia, Stefano, Bill, Marius, Kohlschmidt, Jessica, Pietrzak, Maciej, Walker, Christopher J., Carroll, Andrew J., Braess, Jan, Powell, Bayard L., Eisfeld, Ann-Kathrin, Uy, Geoffrey L., Wang, Eunice S., Kolitz, Jonathan E., Stone, Richard M., Hiddemann, Wolfgang, Byrd, John C., Bloomfield, Clara D., Garzon, Ramiro
Publicado 2021

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

por Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro
Publicado 2019

Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

por Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro
Publicado 2020

Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

por Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro
Publicado 2020