Crystallization and X-ray data analysis of the 10 kDa C-terminal lid subdomain from Caenorhabditis elegans Hsp70

por Worrall, Liam, Walkinshaw, Malcolm D.
Publicado 2006

Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antige...

por Ludwig, Cornelia, Wear, Martin A., Walkinshaw, Malcolm D.
Publicado 2010

Structure- and Ligand-Based Virtual Screening Identifies New Scaffolds for Inhibitors of the Oncoprotein MDM2

por Houston, Douglas R., Yen, Li-Hsuan, Pettit, Simon, Walkinshaw, Malcolm D.
Publicado 2015

A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A

por Wear, Martin A., Patterson, Alan, Malone, Kirk, Dunsmore, Colin, Turner, Nicholas J., Walkinshaw, Malcolm D.
Publicado 2005

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

por Fernandes, Peter M., Kinkead, James, McNae, Iain, Michels, Paul A.M., Walkinshaw, Malcolm D.
Publicado 2020

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

por Nare, Zandile, Moses, Tessa, Burgess, Karl, Schnaufer, Achim, Walkinshaw, Malcolm D., Michels, Paul A. M.
Publicado 2023

Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200

por Wear, Martin A., Nowicki, Matthew W., Blackburn, Elizabeth A., McNae, Iain W., Walkinshaw, Malcolm D.
Publicado 2017

EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities

por Hsin, Kun-Yi, Morgan, Hugh P., Shave, Steven R., Hinton, Andrew C., Taylor, Paul, Walkinshaw, Malcolm D.
Publicado 2011

Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties

por Gur, Mert, Blackburn, Elizabeth A., Ning, Jia, Narayan, Vikram, Ball, Kathryn L., Walkinshaw, Malcolm D., Erman, Burak
Publicado 2018

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

por Fernandes, Peter M., Kinkead, James, McNae, Iain W., Bringaud, Frédéric, Michels, Paul A.M., Walkinshaw, Malcolm D.
Publicado 2019

Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31

por France, David J., Stepek, Gillian, Houston, Douglas R., Williams, Lewis, McCormack, Gillian, Walkinshaw, Malcolm D., Page, Antony P.
Publicado 2015

UFSRAT: Ultra-Fast Shape Recognition with Atom Types –The Discovery of Novel Bioactive Small Molecular Scaffolds for FKBP12 and 11βHSD1

por Shave, Steven, Blackburn, Elizabeth A., Adie, Jillian, Houston, Douglas R., Auer, Manfred, Webster, Scott P., Taylor, Paul, Walkinshaw, Malcolm D.
Publicado 2015

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

por Morgan, Hugh P., Zhong, Wenhe, McNae, Iain W., Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado 2014

Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90

por Blackburn, Elizabeth A., Wear, Martin A., Landré, Vivian, Narayan, Vikram, Ning, Jia, Erman, Burak, Ball, Kathryn L., Walkinshaw, Malcolm D.
Publicado 2015

Protein–Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)

por Narayan, Vikram, Landré, Vivien, Ning, Jia, Hernychova, Lenka, Muller, Petr, Verma, Chandra, Walkinshaw, Malcolm D., Blackburn, Elizabeth A., Ball, Kathryn L.
Publicado 2015

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

por Yuan, Meng, Vásquez-Valdivieso, Montserrat G., McNae, Iain W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado 2017

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogen...

por Fernandes, Peter M., Kinkead, James, McNae, Iain W., Vásquez‐Valdivieso, Monserrat, Wear, Martin A., Michels, Paul A. M., Walkinshaw, Malcolm D.
Publicado 2020

Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

por Teo, Chian Ying, Shave, Steven, Thean Chor, Adam Leow, Salleh, Abu Bakar, Abdul Rahman, Mohd Basyaruddin Bin, Walkinshaw, Malcolm D, Tejo, Bimo A
Publicado 2012

Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach

por Morgan, Hugh P., Estibeiro, Peter, Wear, Martin A., Max, Klaas E.A., Heinemann, Udo, Cubeddu, Liza, Gallagher, Maurice P., Sadler, Peter J., Walkinshaw, Malcolm D.
Publicado 2007

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

por Walker, Roderick G., Thomson, Graeme, Malone, Kirk, Nowicki, Matthew W., Brown, Elaine, Blake, David G., Turner, Nicholas J., Walkinshaw, Malcolm D., Grant, Karen M., Mottram, Jeremy C.
Publicado 2011