Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids

por Pettke, Aleksandra, Tampere, Marianna, Pronk, Robin, Wallner, Olov, Falk, Anna, Warpman Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Puumalainen, Marjo-Riitta
Publicado 2020

Pharmacological OGG1 inhibition decreases murine allergic airway inflammation

por Tanner, Lloyd, Bergwik, Jesper, Bhongir, Ravi K. V., Pan, Lang, Dong, Caijuan, Wallner, Olov, Kalderén, Christina, Helleday, Thomas, Boldogh, Istvan, Adner, Mikael, Egesten, Arne
Publicado 2022

Computational and Experimental Druggability Assessment of Human DNA Glycosylases

por Michel, Maurice, Visnes, Torkild, Homan, Evert J., Seashore-Ludlow, Brinton, Hedenström, Mattias, Wiita, Elisée, Vallin, Karl, Paulin, Cynthia B. J., Zhang, Jiaxi, Wallner, Olov, Scobie, Martin, Schmidt, Andreas, Jenmalm-Jensen, Annika, Warpman Berglund, Ulrika, Helleday, Thomas
Publicado 2019

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

por Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana
Publicado 2021

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

por Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål
Publicado 2021

Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

por Tampere, Marianna, Pettke, Aleksandra, Salata, Cristiano, Wallner, Olov, Koolmeister, Tobias, Cazares-Körner, Armando, Visnes, Torkild, Hesselman, Maria Carmen, Kunold, Elena, Wiita, Elisee, Kalderén, Christina, Lightowler, Molly, Jemth, Ann-Sofie, Lehtiö, Janne, Rosenquist, Åsa, Warpman-Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Jafari, Rozbeh, Puumalainen, Marjo-Riitta
Publicado 2020

Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1

por Wallner, Olov, Cázares‐Körner, Armando, Scaletti, Emma Rose, Masuyer, Geoffrey, Bekkhus, Tove, Visnes, Torkild, Mamonov, Kirill, Ortis, Florian, Lundbäck, Thomas, Volkova, Maria, Koolmeister, Tobias, Wiita, Elisée, Loseva, Olga, Pandey, Monica, Homan, Evert, Benítez‐Buelga, Carlos, Davies, Jonathan, Scobie, Martin, Warpman Berglund, Ulrika, Kalderén, Christina, Stenmark, Pål, Helleday, Thomas, Michel, Maurice
Publicado 2022

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

por Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Publicado 2018

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

por Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Publicado 2019

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

por Sanjiv, Kumar, Calderón-Montaño, José Manuel, Pham, Therese M., Erkers, Tom, Tsuber, Viktoriia, Almlöf, Ingrid, Höglund, Andreas, Heshmati, Yaser, Seashore-Ludlow, Brinton, Nagesh Danda, Akhilesh, Gad, Helge, Wiita, Elisee, Göktürk, Camilla, Rasti, Azita, Friedrich, Stefanie, Centio, Anders, Estruch, Montserrat, Våtsveen, Thea Kristin, Struyf, Nona, Visnes, Torkild, Scobie, Martin, Koolmeister, Tobias, Henriksson, Martin, Wallner, Olov, Sandvall, Teresa, Lehmann, Sören, Theilgaard-Mönch, Kim, Garnett, Mathew J., Östling, Päivi, Walfridsson, Julian, Helleday, Thomas, Warpman Berglund, Ulrika
Publicado 2021

Development of a chemical probe against NUDT15

por Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C.K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Publicado 2020

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

por Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas
Publicado 2020