Alzheimer's disease: synaptic dysfunction and Aβ

por Shankar, Ganesh M, Walsh, Dominic M
Publicado 2009

Lessons from a Rare Familial Dementia: Amyloid and Beyond

por Cantlon, Adam, Frigerio, Carlo Sala, Walsh, Dominic M.
Publicado 2015

Methods for the isolation and analysis of Aβ from postmortem brain

por Hong, Wei, Liu, Wen, Desousa, Alexandra O., Young-Pearse, Tracy, Walsh, Dominic M.
Publicado 2023

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

por Boland, Barry, Smith, David A., Mooney, Declan, Jung, Sonia S., Walsh, Dominic M., Platt, Frances M.
Publicado 2010

Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid β-protein

por Podracky, Christopher J., An, Chihui, DeSousa, Alexandra, Dorr, Brent M., Walsh, Dominic M., Liu, David R.
Publicado 2021

A facile method for expression and purification of the Alzheimer’s disease-associated amyloid β-peptide

por Walsh, Dominic M, Thulin, Eva, Minogue, Aedín M, Gustavsson, Niklas, Pang, Eric, Teplow, David B, Linse, Sara
Publicado 2009

Intracerebroventricular Administration of Amyloid β-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat

por O'Shea, Sean D., Smith, Imelda M., McCabe, Olive M., Cronin, Michelle M., Walsh, Dominic M., O'Connor, William T.
Publicado 2008

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

por Yang, Ting, Dang, Yifan, Ostaszewski, Beth, Mengel, David, Steffen, Verena, Rabe, Christina, Bittner, Tobias, Walsh, Dominic M., Selkoe, Dennis J.
Publicado 2019

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity

por Hu, Neng-Wei, Corbett, Grant T., Moore, Steven, Klyubin, Igor, O’Malley, Tiernan T., Walsh, Dominic M., Livesey, Frederick J., Rowan, Michael J.
Publicado 2018

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

por Yang, Ting, O’Malley, Tiernan T, Kanmert, Daniel, Jerecic, Jasna, Zieske, Lynn R, Zetterberg, Henrik, Hyman, Bradley T, Walsh, Dominic M, Selkoe, Dennis J
Publicado 2015

NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression

por Mengel, David, Mok, Tze How, Nihat, Akin, Liu, Wen, Rissman, Robert A., Galasko, Douglas, Zetterberg, Henrik, Mead, Simon, Collinge, John, Walsh, Dominic M.
Publicado 2021

IgG Conformer's Binding to Amyloidogenic Aggregates

por Phay, Monichan, Welzel, Alfred T., Williams, Angela D., McWilliams-Koeppen, Helen P., Blinder, Veronika, O'Malley, Tiernan T., Solomon, Alan, Walsh, Dominic M., O'Nuallain, Brian
Publicado 2015

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients

por Cha, Diana J., Mengel, David, Mustapic, Maja, Liu, Wen, Selkoe, Dennis J., Kapogiannis, Dimitrios, Galasko, Douglas, Rissman, Robert A., Bennett, David A., Walsh, Dominic M.
Publicado 2019

Soluble Aβ aggregates can inhibit prion propagation

por Sarell, Claire J., Quarterman, Emma, Yip, Daniel C.-M., Terry, Cassandra, Nicoll, Andrew J., Wadsworth, Jonathan D. F., Farrow, Mark A., Walsh, Dominic M., Collinge, John
Publicado 2017

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

por Mengel, David, Liu, Wen, Glynn, Robert J., Selkoe, Dennis J., Strydom, Andre, Lai, Florence, Rosas, H. Diana, Torres, Amy, Patsiogiannis, Vasiliki, Skotko, Brian, Walsh, Dominic M.
Publicado 2020

Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease

por Mattsson-Carlgren, Niklas, Janelidze, Shorena, Palmqvist, Sebastian, Cullen, Nicholas, Svenningsson, Anna L, Strandberg, Olof, Mengel, David, Walsh, Dominic M, Stomrud, Erik, Dage, Jeffrey L, Hansson, Oskar
Publicado 2020

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

por Hu, Neng-Wei, Nicoll, Andrew J., Zhang, Dainan, Mably, Alexandra J., O’Malley, Tiernan, Purro, Silvia A., Terry, Cassandra, Collinge, John, Walsh, Dominic M., Rowan, Michael J.
Publicado 2014

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

por Welzel, Alfred T., Maggio, John E., Shankar, Ganesh M., Walker, Donald E., Ostaszewski, Beth L., Li, Shaomin, Klyubin, Igor, Rowan, Michael J., Seubert, Peter, Walsh, Dominic M., Selkoe, Dennis J.
Publicado 2014

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

por Guix, Francesc X., Corbett, Grant T., Cha, Diana J., Mustapic, Maja, Liu, Wen, Mengel, David, Chen, Zhicheng, Aikawa, Elena, Young-Pearse, Tracy, Kapogiannis, Dimitrios, Selkoe, Dennis J., Walsh, Dominic M.
Publicado 2018

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics

por Wang, Zemin, Jin, Ming, Hong, Wei, Liu, Wen, Reczek, David, Lagomarsino, Valentina N., Hu, Yuan, Weeden, Tim, Frosch, Matthew P., Young-Pearse, Tracy L., Pradier, Laurent, Selkoe, Dennis, Walsh, Dominic M.
Publicado 2023