Gene enhancer deregulation and epigenetic vulnerability

por Lu, Rui, Wang, Gang Greg
Publicado 2016

Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia

por Lu, Rui, Wang, Gang Greg
Publicado 2017

No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function

por Wang, Jun, Wang, Gang Greg
Publicado 2020

Modulation of the high-order chromatin structure by Polycomb complexes

por Guo, Yiran, Wang, Gang Greg
Publicado 2022

Through the lens of phase separation: intrinsically unstructured protein and chromatin looping

por Cai, Ling, Wang, Gang Greg
Publicado 2023

R-loops: formation, function, and relevance to cell stress

por Allison, David F, Wang, Gang Greg
Publicado 2019

An EZH2-NF-κB regulatory axis drives expression of pro-oncogenic gene signatures in triple negative breast cancer

por Dardis, Gabrielle J., Wang, Jun, Simon, Jeremy M., Wang, Gang Greg, Baldwin, Albert S.
Publicado 2023

Structure and regulation of ZCCHC4 in m(6)A-methylation of 28S rRNA

por Ren, Wendan, Lu, Jiuwei, Huang, Mengjiang, Gao, Linfeng, Li, Dongxu, Wang, Gang Greg, Song, Jikui
Publicado 2019

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation

por Wang, Jun, Park, Kwang-Su, Yu, Xufen, Gong, Weida, Earp, H Shelton, Wang, Gang Greg, Jin, Jian, Cai, Ling
Publicado 2022

Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen

por De Silva, Dinuka, Zhang, Zhentao, Liu, Yuanbo, Parker, Joel S., Xu, Chenxi, Cai, Ling, Wang, Gang Greg, Earp, H. Shelton, Whang, Young E.
Publicado 2019

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

por Park, Kwang‐Su, Qin, Lihuai, Kabir, Md, Luo, Kaixiu, Dale, Brandon, Zhong, Yue, Kim, Arum, Wang, Gang Greg, Kaniskan, Husnu Ümit, Jin, Jian
Publicado 2023

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

por Spangler, Cathy J., Yadav, Satya P., Li, Dongxu, Geil, Carinne N., Smith, Charlotte B., Wang, Gang Greg, Lee, Tae-Hee, McGinty, Robert K.
Publicado 2022

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells

por Xu, Bowen, Cai, Ling, Butler, Jason M., Chen, Dongliang, Lu, Xiongdong, Allison, David F., Lu, Rui, Rafii, Shahin, Parker, Joel S., Zheng, Deyou, Wang, Gang Greg
Publicado 2018

Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations

por Gao, Linfeng, Guo, Yiran, Biswal, Mahamaya, Lu, Jiuwei, Yin, Jiekai, Fang, Jian, Chen, Xinyi, Shao, Zengyu, Huang, Mengjiang, Wang, Yinsheng, Wang, Gang Greg, Song, Jikui
Publicado 2022

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

por Zhang, Yi, Guo, Yiran, Gough, Sheryl M., Zhang, Jinyong, Vann, Kendra R., Li, Kuai, Cai, Ling, Shi, Xiaobing, Aplan, Peter D., Wang, Gang Greg, Kutateladze, Tatiana G.
Publicado 2020

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway

por Franklin, Derek A., Liu, Shijie, Jin, Aiwen, Cui, Pengfei, Guo, Zengli, Arend, Kyle C., Moorman, Nathaniel J., He, Shenghui, Wang, Gang Greg, Wan, Yisong Y., Zhang, Yanping
Publicado 2022

Structural basis for DNMT3A-mediated de novo DNA methylation

por Zhang, Zhi-Min, Lu, Rui, Wang, Pengcheng, Yu, Yang, Chen, Dong-Liang, Gao, Linfeng, Liu, Shuo, Ji, Debin, Rothbart, Scott B, Wang, Yinsheng, Wang, Gang Greg, Song, Jikui
Publicado 2018

A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia

por Ren, Zhihong, Kim, Arum, Huang, Yu-Ting, Pi, Wen-Chieh, Gong, Weida, Yu, Xufen, Qi, Jun, Jin, Jian, Cai, Ling, Roeder, Robert G., Chen, Wei-Yi, Wang, Gang Greg
Publicado 2022

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

por Fan, Huitao, Guo, Yiran, Tsai, Yi-Hsuan, Storey, Aaron J, Kim, Arum, Gong, Weida, Edmondson, Ricky D, Mackintosh, Samuel G, Li, Haitao, Byrum, Stephanie D, Tackett, Alan J, Cai, Ling, Wang, Gang Greg
Publicado 2021

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

por Gao, Linfeng, Emperle, Max, Guo, Yiran, Grimm, Sara A., Ren, Wendan, Adam, Sabrina, Uryu, Hidetaka, Zhang, Zhi-Min, Chen, Dongliang, Yin, Jiekai, Dukatz, Michael, Anteneh, Hiwot, Jurkowska, Renata Z., Lu, Jiuwei, Wang, Yinsheng, Bashtrykov, Pavel, Wade, Paul A., Wang, Gang Greg, Jeltsch, Albert, Song, Jikui
Publicado 2020