Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

por Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J., Allen, Nicholas D., Fraenkel, Ernest, Thompson, Leslie M.
Publicado 2020

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

por Reyes-Ortiz, Andrea M., Abud, Edsel M., Burns, Mara S., Wu, Jie, Hernandez, Sarah J., McClure, Nicolette, Wang, Keona Q., Schulz, Corey J., Miramontes, Ricardo, Lau, Alice, Michael, Neethu, Miyoshi, Emily, Van Vactor, David, Reidling, John C., Blurton-Jones, Mathew, Swarup, Vivek, Poon, Wayne W., Lim, Ryan G., Thompson, Leslie M.
Publicado 2022

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

por Wu, Gong-Her, Smith-Geater, Charlene, Galaz-Montoya, Jesús G., Gu, Yingli, Gupte, Sanket R., Aviner, Ranen, Mitchell, Patrick G., Hsu, Joy, Miramontes, Ricardo, Wang, Keona Q., Geller, Nicolette R., Hou, Cathy, Danita, Cristina, Joubert, Lydia-Marie, Schmid, Michael F., Yeung, Serena, Frydman, Judith, Mobley, William, Wu, Chengbiao, Thompson, Leslie M., Chiu, Wah
Publicado 2023

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

por Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.
Publicado 2021