Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy

por Reyner, Eric, Lum, Bert, Jing, Jing, Kagedal, Matts, Ware, Joseph A., Dickmann, Leslie J.
Publicado 2019

Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

por Pilla Reddy , Venkatesh, Fretland, Adrian J., Zhou, Diansong, Sharma, Shringi, Chen, Buyun, Vishwanathan, Karthick, McGinnity, Dermot F., Xu, Yan, Ware, Joseph A.
Publicado 2021

Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors

por Gadkar, Kapil, Friedrich, Christina, Hurez, Vincent, Ruiz, Maria‐Luisa, Dickmann, Leslie, Kumar Jolly, Mohit, Schutt, Leah, Jin, Jin, Ware, Joseph A., Ramanujan, Saroja
Publicado 2021

Combining “Bottom‐up” and “Top‐down” Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC‐0941) Pharmacokinetics

por Lu, Tong, Fraczkiewicz, Grazyna, Salphati, Laurent, Budha, Nageshwar, Dalziel, Gena, Smelick, Gillian S., Morrissey, Kari M., Davis, John D., Jin, Jin Y., Ware, Joseph A.
Publicado 2017

Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment

por Xu, Yan, Izumi, Raquel, Nguyen, Helen, Kwan, Anna, Kuo, Howard, Madere, Jeannine, Slatter, J. Greg, Podoll, Terry, Vishwanathan, Karthick, Marbury, Thomas, Smith, William, Preston, Richard A., Sharma, Shringi, Ware, Joseph A.
Publicado 2022

Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor

por Ma, Shuguang, Suchomel, Julia, Yanez, Evelyn, Yost, Edward, Liang, Xiaorong, Zhu, Rui, Le, Hoa, Siebers, Nicholas, Joas, Lori, Morley, Roland, Royer‐Joo, Stephanie, Pirzkall, Andrea, Salphati, Laurent, Ware, Joseph A., Morrissey, Kari M.
Publicado 2019

Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration With Proton‐Pump Inhibitors

por Sharma, Shringi, Pepin, Xavier, Burri, Harini, Zheng, Lianqing, Kuptsova‐Clarkson, Nataliya, de Jong, Anouk, Yu, Ting, MacArthur, Holly L., Majewski, Michal, Byrd, John C., Furman, Richard R., Ware, Joseph A., Mann, James, Ramies, David, Munugalavadla, Veerendra, Sheridan, Louise, Tomkinson, Helen
Publicado 2022