On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries

por Stanway‐Gordon, Harriet A., Graham, Jessica S., Waring, Michael J.
Publicado 2021

Development of a Micellar-Promoted Heck Reaction for the Synthesis of DNA-Encoded Libraries

por Stanway-Gordon, Harriet A., Odger, Jake A., Waring, Michael J.
Publicado 2023

Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid

por Uguen, Mélanie, Gai, Conghao, Sprenger, Lukas J., Liu, Hang, Leach, Andrew G., Waring, Michael J.
Publicado 2021

Cyclizations and fragmentations in the alkylation of 6‐chloro‐5‐hydroxy‐4‐aminopyrimidines with aminoalkyl chlorides

por Picazo, Edwige M. H., Heptinstall, Amy B., Wilson, David M., Cano, Céline, Golding, Bernard T., Waring, Michael J.
Publicado 2021

Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex

por Wu, Pei-Ching, Tzeng, Shu-Ling, Chang, Chung-ke, Kao, Ya-Fen, Waring, Michael J, Hou, Ming-Hon
Publicado 2018

2,3-Bifunctionalized Quinoxalines: Synthesis, DNA Interactions and Evaluation of Anticancer, Anti-tuberculosis and Antifungal Activity

por Waring, Michael J., Ben-Hadda, Taibi, Kotchevar, Ann T., Ramdani, Abdelkrim, Touzani, Rachid, Elkadiri, Sghir, Hakkou, Abdelkader, Bouakka, Mohamed, Ellis, Tom
Publicado 2002

Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding

por Naidu, Mamta D., Agarwal, Rakhi, Pena, Louis A., Cunha, Luis, Mezei, Mihaly, Shen, Min, Wilson, David M., Liu, Yuan, Sanchez, Zina, Chaudhary, Pankaj, Wilson, Samuel H., Waring, Michael J.
Publicado 2011

Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics

por Hothersall, J. Daniel, Guo, Dong, Sarda, Sunil, Sheppard, Robert J., Chen, Hongming, Keur, Wesley, Waring, Michael J., IJzerman, Adriaan P., Hill, Stephen J., Dale, Ian L., Rawlins, Philip B.
Publicado 2017

Co(II)(Chromomycin)(2) Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex

por Chen, Yu-Wen, Satange, Roshan, Wu, Pei-Ching, Jhan, Cyong-Ru, Chang, Chung-ke, Chung, Kuang-Ren, Waring, Michael J., Lin, Sheng-Wei, Hsieh, Li-Ching, Hou, Ming-Hon
Publicado 2018

Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries

por Hunter, James H., Anderson, Matthew J., Castan, Isaline F. S. F., Graham, Jessica S., Salvini, Catherine L. A., Stanway-Gordon, Harriet A., Crawford, James J., Madin, Andrew, Pairaudeau, Garry, Waring, Michael J.
Publicado 2021

Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

por Uguen, Mélanie, Davison, Gemma, Sprenger, Lukas J., Hunter, James H., Martin, Mathew P., Turberville, Shannon, Watt, Jessica E., Golding, Bernard T., Noble, Martin E. M., Stewart, Hannah L., Waring, Michael J.
Publicado 2022

Fragment expansion with NUDELs – poised DNA-encoded libraries

por Salvini, Catherine L. A., Darlot, Benoit, Davison, Jack, Martin, Mathew P., Tudhope, Susan J., Turberville, Shannon, Kawamura, Akane, Noble, Martin E. M., Wedge, Stephen R., Crawford, James J., Waring, Michael J.
Publicado 2023

Structure–Affinity Relationships and Structure–Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists

por Xia, Lizi, de Vries, Henk, Lenselink, Eelke B., Louvel, Julien, Waring, Michael J., Cheng, Leifeng, Pahlén, Sara, Petersson, Maria J., Schell, Peter, Olsson, Roine I., Heitman, Laura H., Sheppard, Robert J., IJzerman, Adriaan P.
Publicado 2017

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

por Bosma, Reggie, Stoddart, Leigh A., Georgi, Victoria, Bouzo-Lorenzo, Monica, Bushby, Nick, Inkoom, Loretta, Waring, Michael J., Briddon, Stephen J., Vischer, Henry F., Sheppard, Robert J., Fernández-Montalván, Amaury, Hill, Stephen J., Leurs, Rob
Publicado 2019

Route to Prolonged Residence Time at the Histamine H(1) Receptor: Growing from Desloratadine to Rupatadine

por Bosma, Reggie, Wang, Zhiyong, Kooistra, Albert J., Bushby, Nick, Kuhne, Sebastiaan, van den Bor, Jelle, Waring, Michael J., de Graaf, Chris, de Esch, Iwan J., Vischer, Henry F., Sheppard, Robert J., Wijtmans, Maikel, Leurs, Rob
Publicado 2019

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

por Morese, Pasquale A., Anthony, Nahoum, Bodnarchuk, Michael, Jennings, Claire, Martin, Mathew P., Noble, Richard A., Phillips, Nicole, Thomas, Huw D., Wang, Lan Z., Lister, Andrew, Noble, Martin E. M., Ward, Richard A., Wedge, Stephen R., Stewart, Hannah L., Waring, Michael J.
Publicado 2023

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites—Halogenated Probes of Druglike and Peptide-like Molecular Interactions

por Davison, Gemma, Martin, Mathew P., Turberville, Shannon, Dormen, Selma, Heath, Richard, Heptinstall, Amy B., Lawson, Marie, Miller, Duncan C., Ng, Yi Min, Sanderson, James N., Hope, Ian, Wood, Daniel J., Cano, Céline, Endicott, Jane A., Hardcastle, Ian R., Noble, Martin E. M., Waring, Michael J.
Publicado 2022

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

por Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Publicado 2022

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

por Douangamath, Alice, Fearon, Daren, Gehrtz, Paul, Krojer, Tobias, Lukacik, Petra, Owen, C. David, Resnick, Efrat, Strain-Damerell, Claire, Aimon, Anthony, Ábrányi-Balogh, Péter, Brandão-Neto, José, Carbery, Anna, Davison, Gemma, Dias, Alexandre, Downes, Thomas D., Dunnett, Louise, Fairhead, Michael, Firth, James D., Jones, S. Paul, Keeley, Aaron, Keserü, György M., Klein, Hanna F., Martin, Mathew P., Noble, Martin E. M., O’Brien, Peter, Powell, Ailsa, Reddi, Rambabu N., Skyner, Rachael, Snee, Matthew, Waring, Michael J., Wild, Conor, London, Nir, von Delft, Frank, Walsh, Martin A.
Publicado 2020