Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

por Warminski, Marcin, Sikorski, Pawel J., Kowalska, Joanna, Jemielity, Jacek
Publicado 2017

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by (19)F NMR

por Baranowski, Marek R, Warminski, Marcin, Jemielity, Jacek, Kowalska, Joanna
Publicado 2020

Chemical Modifications of mRNA Ends for Therapeutic Applications

por Warminski, Marcin, Mamot, Adam, Depaix, Anaïs, Kowalska, Joanna, Jemielity, Jacek
Publicado 2023

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks

por Ziemkiewicz, Kamil, Warminski, Marcin, Wojcik, Radoslaw, Kowalska, Joanna, Jemielity, Jacek
Publicado 2022

Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs

por Kozarski, Mateusz, Drazkowska, Karolina, Bednarczyk, Marcelina, Warminski, Marcin, Jemielity, Jacek, Kowalska, Joanna
Publicado 2023

Phosphodiester modifications in mRNA poly(A) tail prevent deadenylation without compromising protein expression

por Strzelecka, Dominika, Smietanski, Miroslaw, Sikorski, Pawel J., Warminski, Marcin, Kowalska, Joanna, Jemielity, Jacek
Publicado 2020

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

por Sikorski, Pawel J, Warminski, Marcin, Kubacka, Dorota, Ratajczak, Tomasz, Nowis, Dominika, Kowalska, Joanna, Jemielity, Jacek
Publicado 2020

Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy

por Wojtczak, Anna, Kasprzyk, Renata, Warmiński, Marcin, Ubych, Krystian, Kubacka, Dorota, Sikorski, Pawel J., Jemielity, Jacek, Kowalska, Joanna
Publicado 2021

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion...

por Drazkowska, Karolina, Tomecki, Rafal, Warminski, Marcin, Baran, Natalia, Cysewski, Dominik, Depaix, Anaïs, Kasprzyk, Renata, Kowalska, Joanna, Jemielity, Jacek, Sikorski, Pawel J
Publicado 2022

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-...

por Warminski, Marcin, Kowalska, Joanna, Nowak, Elzbieta, Kubacka, Dorota, Tibble, Ryan, Kasprzyk, Renata, Sikorski, Pawel J., Gross, John D., Nowotny, Marcin, Jemielity, Jacek
Publicado 2021

Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9

por Bednarczyk, Marcelina, Peters, Jessica K., Kasprzyk, Renata, Starek, Jagoda, Warminski, Marcin, Spiewla, Tomasz, Mugridge, Jeffrey S., Gross, John D., Jemielity, Jacek, Kowalska, Joanna
Publicado 2022

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

por Miedziak, Beata, Dobieżyńska, Anna, Darżynkiewicz, Zbigniew M., Bartkowska, Julia, Miszkiewicz, Joanna, Kowalska, Joanna, Warminski, Marcin, Tyras, Michal, Trylska, Joanna, Jemielity, Jacek, Darzynkiewicz, Edward, Grzela, Renata
Publicado 2020

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

por Galloway, Alison, Kaskar, Aneesa, Ditsova, Dimitrinka, Atrih, Abdelmadjid, Yoshikawa, Harunori, Gomez-Moreira, Carolina, Suska, Olga, Warminski, Marcin, Grzela, Renata, Lamond, Angus I, Darzynkiewicz, Edward, Jemielity, Jacek, Cowling, Victoria H
Publicado 2021

mRNA cap analogues substituted in the tetraphosphate chain with CX(2): identification of O-to-CCl(2) as the first bridging modification that confers resistance to decapping without...

por Rydzik, Anna M., Warminski, Marcin, Sikorski, Pawel J., Baranowski, Marek R., Walczak, Sylwia, Kowalska, Joanna, Zuberek, Joanna, Lukaszewicz, Maciej, Nowak, Elzbieta, W. Claridge, Timothy D., Darzynkiewicz, Edward, Nowotny, Marcin, Jemielity, Jacek
Publicado 2017