Allosteric Antagonism of Insect Odorant Receptor Ion Channels

por Jones, Patrick L., Pask, Gregory M., Romaine, Ian M., Taylor, Robert W., Reid, Paul R., Waterson, Alex G., Sulikowski, Gary A., Zwiebel, Laurence J.
Publicado 2012

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition

por An, Hanbing, Stoops, Sydney L., Deane, Natasha G., Zhu, Jing, Zi, Jinghuan, Weaver, Connie, Waterson, Alex G., Zijlstra, Andries, Lindsley, Craig W., Beauchamp, Robert Daniel
Publicado 2015

Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma

por Rellinger, Eric J., Padmanabhan, Chandrasekhar, Qiao, Jingbo, Craig, Brian T., An, Hanbing, Zhu, Jing, Correa, Hernán, Waterson, Alex G., Lindsley, Craig W., Beauchamp, R. Daniel, Chung, Dai H.
Publicado 2017

cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition

por Padmanabhan, Chandrasekhar, Rellinger, Eric J., Zhu, Jing, An, Hanbing, Woodbury, Luke G., Chung, Dai H., Waterson, Alex G., Lindsley, Craig W., Means, Anna L., Beauchamp, R. Daniel
Publicado 2017

High-Content Imaging Platform to Discover Chemical Modulators of Plasma Membrane Rafts

por Fricke, Nico, Raghunathan, Krishnan, Tiwari, Ajit, Stefanski, Katherine M., Balakrishnan, Muthuraj, Waterson, Alex G., Capone, Ricardo, Huang, Hui, Sanders, Charles R., Bauer, Joshua A., Kenworthy, Anne K.
Publicado 2022

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

por Frank, Andreas O., Vangamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Luzwick, Jessica W., Cortez, David, Olejniczak, Edward T., Waterson, Alex G., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publicado 2014

Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages

por Zarrow, Jonah E., Alli-Oluwafuyi, Abdul-Musawwir, Youwakim, Cristina M., Kim, Kwangho, Jenkins, Andrew N., Suero, Isabelle C., Jones, Margaret R., Mashhadi, Zahra, Mackie, Kenneth P., Waterson, Alex G., Doran, Amanda C., Sulikowski, Gary A., Davies, Sean S.
Publicado 2023

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS(G12C) Inhibitor

por Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen
Publicado 2022

Drugging an undruggable pocket on KRAS

por Kessler, Dirk, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Publicado 2019

Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers

por Kessler, Dirk, Gollner, Andreas, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Publicado 2020

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

por Oshima, Nobu, Ishida, Ryo, Kishimoto, Shun, Beebe, Kristin, Brender, Jeffrey R., Yamamoto, Kazutoshi, Urban, Daniel, Rai, Ganesha, Johnson, Michelle S., Benavides, Gloria, Squadrito, Giuseppe L., Crooks, Dan, Jackson, Joseph, Joshi, Abhinav, Mott, Bryan T., Shrimp, Jonathan H., Moses, Michael A., Lee, Min-Jung, Yuno, Akira, Lee, Tobie D., Hu, Xin, Anderson, Tamara, Kusewitt, Donna, Hathaway, Helen H., Jadhav, Ajit, Picard, Didier, Trepel, Jane B., Mitchell, James B., Stott, Gordon M., Moore, William, Simeonov, Anton, Sklar, Larry A., Norenberg, Jeffrey P., Linehan, W. Marston, Maloney, David J., Dang, Chi V., Waterson, Alex G., Hall, Matthew, Darley-Usmar, Victor M., Krishna, Murali C., Neckers, Leonard M.
Publicado 2020