Understanding hepatotoxicity – from patients to mice to computer

por Watkins, Paul B
Publicado 2012

Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling

por Watkins, Paul B.
Publicado 2018

The DILI‐sim Initiative: Insights into Hepatotoxicity Mechanisms and Biomarker Interpretation

por Watkins, Paul B.
Publicado 2019

The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates

por Church, Rachel J., Watkins, Paul B.
Publicado 2020

Spatial pattern of intra-laminar connectivity in supragranular mouse auditory cortex

por Watkins, Paul V., Kao, Joseph P. Y., Kanold, Patrick O.
Publicado 2014

Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury

por Borlak, Jürgen, Chatterji, Bijon, Londhe, Kishor B, Watkins, Paul B
Publicado 2013

Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial

por Watkins, Paul B., Church, Rachel J., Li, Jie, Knappertz, Volker
Publicado 2020

The Effects of Auditory Contrast Tuning upon Speech Intelligibility

por Killian, Nathan J., Watkins, Paul V., Davidson, Lisa S., Barbour, Dennis L.
Publicado 2016

Identification of Identical Transcript Changes in Liver and Whole Blood during Acetaminophen Toxicity

por Zhang, Liwen, Bushel, Pierre R., Chou, Jeff, Zhou, Tong, Watkins, Paul B.
Publicado 2012

Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials)

por Kullak-Ublick, Gerd A., Merz, Michael, Griffel, Louis, Kaplowitz, Neil, Watkins, Paul B.
Publicado 2014

Extracellular space preservation aids the connectomic analysis of neural circuits

por Pallotto, Marta, Watkins, Paul V, Fubara, Boma, Singer, Joshua H, Briggman, Kevin L
Publicado 2015

Methodology to Assess Clinical Liver Safety Data

por Merz, Michael, Lee, Kwan R., Kullak-Ublick, Gerd A., Brueckner, Andreas, Watkins, Paul B.
Publicado 2014

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

por Yang, Kyunghee, Woodhead, Jeffrey L, Watkins, Paul B, Howell, Brett A, Brouwer, Kim LR
Publicado 2014

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

por Woodhead, Jeffrey L, Siler, Scott Q, Howell, Brett A, Watkins, Paul B, Conway, Charles
Publicado 2022

Acid extrusion via blood–brain barrier causes brain alkalosis and seizures after neonatal asphyxia

por Helmy, Mohamed M., Ruusuvuori, Eva, Watkins, Paul V., Voipio, Juha, Kanold, Patrick O., Kaila, Kai
Publicado 2012

Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine

por Singhal, Rohit, Harrill, Alison H, Menguy-Vacheron, Francoise, Jayyosi, Zaid, Benzerdjeb, Hadj, Watkins, Paul B
Publicado 2014

The Clinical Liver Safety Assessment Best Practices Workshop: Rationale, Goals, Accomplishments and the Future

por Watkins, Paul B., Merz, Michael, Avigan, Mark I., Kaplowitz, Neil, Regev, Arie, Senior, John R.
Publicado 2014

Very Long-Chain Acyl-CoA Synthetase 3: Overexpression and Growth Dependence in Lung Cancer

por Pei, Zhengtong, Fraisl, Peter, Shi, Xiaohai, Gabrielson, Edward, Forss-Petter, Sonja, Berger, Johannes, Watkins, Paul A.
Publicado 2013

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

por Sun, Peng, Xia, Shuli, Lal, Bachchu, Shi, Xiaohai, Yang, Kil Sung, Watkins, Paul A, Laterra, John
Publicado 2014

Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)

por Recuero-Checa, Maria A., Sharma, Manu, Lau, Constance, Watkins, Paul A., Gaydos, Charlotte A., Dean, Deborah
Publicado 2016