Understanding hepatotoxicity – from patients to mice to computer

por Watkins, Paul B
Publicado 2012

Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling

por Watkins, Paul B.
Publicado 2018

The DILI‐sim Initiative: Insights into Hepatotoxicity Mechanisms and Biomarker Interpretation

por Watkins, Paul B.
Publicado 2019

The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates

por Church, Rachel J., Watkins, Paul B.
Publicado 2020

Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury

por Borlak, Jürgen, Chatterji, Bijon, Londhe, Kishor B, Watkins, Paul B
Publicado 2013

Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial

por Watkins, Paul B., Church, Rachel J., Li, Jie, Knappertz, Volker
Publicado 2020

Identification of Identical Transcript Changes in Liver and Whole Blood during Acetaminophen Toxicity

por Zhang, Liwen, Bushel, Pierre R., Chou, Jeff, Zhou, Tong, Watkins, Paul B.
Publicado 2012

Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials)

por Kullak-Ublick, Gerd A., Merz, Michael, Griffel, Louis, Kaplowitz, Neil, Watkins, Paul B.
Publicado 2014

Methodology to Assess Clinical Liver Safety Data

por Merz, Michael, Lee, Kwan R., Kullak-Ublick, Gerd A., Brueckner, Andreas, Watkins, Paul B.
Publicado 2014

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

por Yang, Kyunghee, Woodhead, Jeffrey L, Watkins, Paul B, Howell, Brett A, Brouwer, Kim LR
Publicado 2014

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

por Woodhead, Jeffrey L, Siler, Scott Q, Howell, Brett A, Watkins, Paul B, Conway, Charles
Publicado 2022

Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine

por Singhal, Rohit, Harrill, Alison H, Menguy-Vacheron, Francoise, Jayyosi, Zaid, Benzerdjeb, Hadj, Watkins, Paul B
Publicado 2014

The Clinical Liver Safety Assessment Best Practices Workshop: Rationale, Goals, Accomplishments and the Future

por Watkins, Paul B., Merz, Michael, Avigan, Mark I., Kaplowitz, Neil, Regev, Arie, Senior, John R.
Publicado 2014

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses

por Shoda, Lisl KM, Battista, Christina, Siler, Scott Q, Pisetsky, David S, Watkins, Paul B, Howell, Brett A
Publicado 2017

Causality Assessment for Suspected DILI During Clinical Phases of Drug Development

por Regev, Arie, Seeff, Leonard B., Merz, Michael, Ormarsdottir, Sif, Aithal, Guruprasad P., Gallivan, Jim, Watkins, Paul B.
Publicado 2014

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

por Norona, Leah M., Nguyen, Deborah G., Gerber, David A., Presnell, Sharon C., Mosedale, Merrie, Watkins, Paul B.
Publicado 2019

Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

por McLaughlin, Jacqueline E., Layton, Rebekah L., Watkins, Paul B., Nicholas, Robert A., Brouwer, Kim L. R.
Publicado 2022

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

por Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Publicado 2018

Mechanistic Investigations Support Liver Safety of Ubrogepant

por Smith, Brenda, Rowe, Josh, Watkins, Paul B, Ashina, Messoud, Woodhead, Jeffrey L, Sistare, Frank D, Goadsby, Peter J
Publicado 2020

Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables

por Tyson, Rachel J., Park, Christine C., Powell, J. Robert, Patterson, J. Herbert, Weiner, Daniel, Watkins, Paul B., Gonzalez, Daniel
Publicado 2020