Fighting in a wasteland: deleterious metabolites and antitumor immunity

por Watson, McLane J., Delgoffe, Greg M.
Publicado 2022

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

por Menk, Ashley V., Scharping, Nicole E., Rivadeneira, Dayana B., Calderon, Michael J., Watson, McLane J., Dunstane, Deanna, Watkins, Simon C., Delgoffe, Greg M.
Publicado 2018

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

por Lontos, Konstantinos, Wang, Yiyang, Joshi, Supriya K, Frisch, Andrew T, Watson, McLane J, Kumar, Alok, Menk, Ashley V, Wang, Yupeng, Cumberland, Rachel, Lohmueller, Jason, Carrizosa, Esteban, Boyerinas, Benjamin, Delgoffe, Greg M
Publicado 2023

An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment

por DePeaux, Kristin, Rivadeneira, Dayana B., Lontos, Konstantinos, Dean, Victoria G., Gunn, William G., Watson, McLane J., Yao, Tianhong, Wilfahrt, Drew, Hinck, Cynthia, Wieteska, Lukasz, Thorne, Stephen H., Hinck, Andrew P., Delgoffe, Greg M.
Publicado 2023

Carbon source availability drives nutrient utilization in CD8(+) T cells

por Kaymak, Irem, Luda, Katarzyna M., Duimstra, Lauren R., Ma, Eric H., Longo, Joseph, Dahabieh, Michael S., Faubert, Brandon, Oswald, Brandon M., Watson, McLane J., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Compton, Shelby E., Fu, Zhen, DeBerardinis, Ralph J., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.
Publicado 2022

Metabolic support of tumor-infiltrating regulatory T cells by lactic acid

por Watson, McLane J., Vignali, Paolo D.A., Mullett, Steven J., Overacre-Delgoffe, Abigail E., Peralta, Ronal M., Grebinoski, Stephanie, Menk, Ashley V., Rittenhouse, Natalie L., DePeaux, Kristin, Whetstone, Ryan D., Vignali, Dario A. A., Hand, Timothy W., Poholek, Amanda C., Morrison, Brett M., Rothstein, Jeffrey D., Wendell, Stacy G., Delgoffe, Greg M.
Publicado 2021

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors

por Zappasodi, Roberta, Serganova, Inna, Cohen, Ivan J., Maeda, Masatomo, Shindo, Masahiro, Senbabaoglu, Yasin, Watson, McLane J., Leftin, Avigdor, Maniyar, Rachana, Verma, Svena, Lubin, Matthew, Ko, Myat, Mane, Mayuresh M., Zhong, Hong, Liu, Cailian, Ghosh, Arnab, Abu-Akeel, Mohsen, Ackerstaff, Ellen, Koutcher, Jason A., Ho, Ping-Chih, Delgoffe, Greg M., Blasberg, Ronald, Wolchok, Jedd D., Merghoub, Taha
Publicado 2021