Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

por Watt, Joanna M., Graeff, Richard, Potter, Barry V. L.
Publicado 2021

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

por Watt, Joanna M., Thomas, Mark P., Potter, Barry V. L.
Publicado 2018

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”

por Watt, Joanna M., Graeff, Richard, Thomas, Mark P., Potter, Barry V. L.
Publicado 2017

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

por Kühn, Frank J. P., Watt, Joanna M., Potter, Barry V. L., Lückhoff, Andreas
Publicado 2019

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

por Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Guse, Andreas H., Fliegert, Ralf, Potter, Barry V. L.
Publicado 2019

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)

por Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Fliegert, Ralf, Guse, Andreas H., Potter, Barry V. L.
Publicado 2020

Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors

por Su, Xiangdong, Dohle, Wolfgang, Mills, Stephen J., Watt, Joanna M., Rossi, Ana M., Taylor, Colin W., Potter, Barry V. L.
Publicado 2020

Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

por Zhang, Bo, Watt, Joanna M, Cordiglieri, Chiara, Dammermann, Werner, Mahon, Mary F., Flügel, Alexander, Guse, Andreas H., Potter, Barry V. L.
Publicado 2018

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis

por Vara, Dina, Watt, Joanna M., Fortunato, Tiago M., Mellor, Harry, Burgess, Matthew, Wicks, Kate, Mace, Kimberly, Reeksting, Shaun, Lubben, Anneke, Wheeler-Jones, Caroline P.D., Pula, Giordano
Publicado 2018

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

por Fliegert, Ralf, Watt, Joanna M., Schöbel, Anja, Rozewitz, Monika D., Moreau, Christelle, Kirchberger, Tanja, Thomas, Mark P., Sick, Wiebke, Araujo, Andrea C., Harneit, Angelika, Potter, Barry V.L., Guse, Andreas H.
Publicado 2017