Structural insight into nucleotide recognition by human death-associated protein kinase

por McNamara, Laurie K., Watterson, D. Martin, Brunzelle, Joseph S.
Publicado 2009

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

por Bachstetter, Adam D., Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2014

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid

por Craft, Jeffrey M, Watterson, D Martin, Hirsch, Emmet, Van Eldik, Linda J
Publicado 2005

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target

por Borders, Aaron S, de Almeida, Lucia, Van Eldik, Linda J, Watterson, D Martin
Publicado 2008

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse mo...

por Lloyd, Eric, Somera-Molina, Kathleen, Van Eldik, Linda J, Watterson, D Martin, Wainwright, Mark S
Publicado 2008

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

por Bachstetter, Adam D, Xing, Bin, de Almeida, Lucia, Dimayuga, Edgardo R, Watterson, D Martin, Van Eldik, Linda J
Publicado 2011

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

por Bachstetter, Adam D, Webster, Scott J, Goulding, Danielle S, Morton, Jonathan E, Watterson, D Martin, Van Eldik, Linda J
Publicado 2015

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

por Zhou, Zhengqiu, Bachstetter, Adam D., Späni, Claudia B., Roy, Saktimayee M., Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2017

Generation and Behavior Characterization of CaMKIIβ Knockout Mice

por Bachstetter, Adam D., Webster, Scott J., Tu, Tao, Goulding, Danielle S., Haiech, Jacques, Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2014

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and de...

por Braun, David J., Bachstetter, Adam D., Sudduth, Tiffany L., Wilcock, Donna M., Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2019

A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells

por Glover, Loren E., Tajiri, Naoki, Weinbren, Nathan L., Ishikawa, Hiroto, Shinozuka, Kazutaka, Kaneko, Yuji, Watterson, D. Martin, Borlongan, Cesar V.
Publicado 2011

Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy

por Simon, Christian M., Van Alstyne, Meaghan, Lotti, Francesco, Bianchetti, Elena, Tisdale, Sarah, Watterson, D. Martin, Mentis, George Z., Pellizzoni, Livio
Publicado 2019

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorb...

por Braun, David J., Powell, David K., McLouth, Christopher J., Roy, Saktimayee M., Watterson, D. Martin, Van Eldik, Linda J.
Publicado 2022

Critical Role of Non-Muscle Myosin Light Chain Kinase in Thrombin-Induced Endothelial Cell Inflammation and Lung PMN Infiltration

por Fazal, Fabeha, Bijli, Kaiser M., Murrill, Matthew, Leonard, Antony, Minhajuddin, Mohammad, Anwar, Khandaker N., Finkelstein, Jacob N., Watterson, D. Martin, Rahman, Arshad
Publicado 2013

Product release is rate-limiting for catalytic processing by the Dengue virus protease

por Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G., Young, P. R.
Publicado 2016

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

por Roy, Saktimayee M., Minasov, George, Arancio, Ottavio, Chico, Laura W., Van Eldik, Linda J., Anderson, Wayne F., Pelletier, Jeffrey C., Watterson, D. Martin
Publicado 2019

Correction to “A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunctio...

por Roy, Saktimayee M., Minasov, George, Arancio, Ottavio, Chico, Laura W., Van Eldik, Linda J., Anderson, Wayne F., Pelletier, Jeffrey C., Watterson, D. Martin
Publicado 2020

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

por Maphis, Nicole, Jiang, Shanya, Xu, Guixiang, Kokiko-Cochran, Olga N., Roy, Saktimayee M., Van Eldik, Linda J., Watterson, D. Martin, Lamb, Bruce T., Bhaskar, Kiran
Publicado 2016

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

por Robson, Matthew J., Quinlan, Meagan A., Margolis, Kara Gross, Gajewski-Kurdziel, Paula A., Veenstra-VanderWeele, Jeremy, Gershon, Michael D., Watterson, D. Martin, Blakely, Randy D.
Publicado 2018

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation

por Schmid, Michael C., Kang, Sang Won, Chen, Hui, Paradise, Marc, Ghebremedhin, Anghesom, Kaneda, Megan M., Chin, Shao-Ming, Do, Anh, Watterson, D. Martin, Varner, Judith A.
Publicado 2022